Human pegivirus-1 associated leukoencephalitis : Clinical and molecular features
© 2018 American Neurological Association..
Etiologic diagnosis is uncertain in 35% to 50% of patients with encephalitis, despite its substantial global prevalence and disease burden. We report on 2 adult female patients with fatal leukoencephalitis associated with human pegivirus-1 (HPgV-1) brain infection. Neuroimaging showed inflammatory changes in cerebral white matter. Brain-derived HPgV-1 RNA sequences clustered phylogenetically with other pegiviruses despite an 87-nucleotide deletion in the viral nonstructural (NS)2 gene. Neuropathology disclosed lymphocyte infiltration and gliosis predominantly in brain white matter. HPgV-1 NS5A antigen was detected in lymphocytes as well as in astrocytes and oligodendrocytes. HPgV-1 neuroadaptation should be considered in the differential diagnosis of progressive leukoencephalitis in humans. Ann Neurol 2018;84:789-795.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:84 |
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| Enthalten in: |
Annals of neurology - 84(2018), 5 vom: 21. Nov., Seite 781-787 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Balcom, Erin F [VerfasserIn] |
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| Anmerkungen: |
Date Completed 21.08.2019 Date Revised 21.08.2019 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/ana.25343 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM288832906 |
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| 245 | 1 | 0 | |a Human pegivirus-1 associated leukoencephalitis |b Clinical and molecular features |
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| 500 | |a Date Revised 21.08.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2018 American Neurological Association. | ||
| 520 | |a Etiologic diagnosis is uncertain in 35% to 50% of patients with encephalitis, despite its substantial global prevalence and disease burden. We report on 2 adult female patients with fatal leukoencephalitis associated with human pegivirus-1 (HPgV-1) brain infection. Neuroimaging showed inflammatory changes in cerebral white matter. Brain-derived HPgV-1 RNA sequences clustered phylogenetically with other pegiviruses despite an 87-nucleotide deletion in the viral nonstructural (NS)2 gene. Neuropathology disclosed lymphocyte infiltration and gliosis predominantly in brain white matter. HPgV-1 NS5A antigen was detected in lymphocytes as well as in astrocytes and oligodendrocytes. HPgV-1 neuroadaptation should be considered in the differential diagnosis of progressive leukoencephalitis in humans. Ann Neurol 2018;84:789-795 | ||
| 650 | 4 | |a Case Reports | |
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| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Doan, Matthew A L |e verfasserin |4 aut | |
| 700 | 1 | |a Branton, William G |e verfasserin |4 aut | |
| 700 | 1 | |a Jovel, Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Blevins, Gregg |e verfasserin |4 aut | |
| 700 | 1 | |a Edguer, Beste |e verfasserin |4 aut | |
| 700 | 1 | |a Hobman, Tom C |e verfasserin |4 aut | |
| 700 | 1 | |a Yacyshyn, Elaine |e verfasserin |4 aut | |
| 700 | 1 | |a Emery, Derek |e verfasserin |4 aut | |
| 700 | 1 | |a Box, Adrian |e verfasserin |4 aut | |
| 700 | 1 | |a van Landeghem, Frank K H |e verfasserin |4 aut | |
| 700 | 1 | |a Power, Christopher |e verfasserin |4 aut | |
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