A case of severe metformin-associated lactic acidosis treated with CVVHDF and regional anticoagulation with sodium citrate
Copyright by Società Italiana di Nefrologia SIN, Rome, Italy..
Metformin is an antidiabetic drug; used to treat type II diabetes mellitus, metformin associated lactic acidosis has an incidence of 2-9 cases / 100,000 patients / year with high mortality (30%). We have had the case of a 75-year-old woman with metabolic acidosis as a result of metformin assumption, treated by renal replacement therapy (CRRT) with continuous veno-venous hemodiafiltration (CVVHDF).
RESULTS: after a short treatment period there was a reduction in Lactates (from 16.8 mmol/L to 12.6 mmol/L) and a progressive improvement of acidosis. In 72 hours the recovery of diuresis and subsequent suspension of CRRT was achieved.
CONCLUSION: CRRT, in addition to ensuring support for renal failure and volume correction, allowed a rapid recovery from metformin-associated lactic acidosis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
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| Enthalten in: |
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia - 35(2018), 5 vom: 10. Sept. |
| Sprache: |
Italienisch |
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| Beteiligte Personen: |
Ferrario, Matteo [VerfasserIn] |
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| Anmerkungen: |
Date Completed 19.02.2019 Date Revised 20.03.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM288708563 |
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| 245 | 1 | 2 | |a A case of severe metformin-associated lactic acidosis treated with CVVHDF and regional anticoagulation with sodium citrate |
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| 500 | |a Date Completed 19.02.2019 | ||
| 500 | |a Date Revised 20.03.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright by Società Italiana di Nefrologia SIN, Rome, Italy. | ||
| 520 | |a Metformin is an antidiabetic drug; used to treat type II diabetes mellitus, metformin associated lactic acidosis has an incidence of 2-9 cases / 100,000 patients / year with high mortality (30%). We have had the case of a 75-year-old woman with metabolic acidosis as a result of metformin assumption, treated by renal replacement therapy (CRRT) with continuous veno-venous hemodiafiltration (CVVHDF) | ||
| 520 | |a RESULTS: after a short treatment period there was a reduction in Lactates (from 16.8 mmol/L to 12.6 mmol/L) and a progressive improvement of acidosis. In 72 hours the recovery of diuresis and subsequent suspension of CRRT was achieved | ||
| 520 | |a CONCLUSION: CRRT, in addition to ensuring support for renal failure and volume correction, allowed a rapid recovery from metformin-associated lactic acidosis | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a lactic acidosis | |
| 650 | 4 | |a CRRT | |
| 650 | 4 | |a CVVHDF | |
| 650 | 4 | |a metformin | |
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| 650 | 7 | |a Piperacillin, Tazobactam Drug Combination |2 NLM | |
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| 650 | 7 | |a Sodium Citrate |2 NLM | |
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| 700 | 1 | |a Della Morte, Mauro |e verfasserin |4 aut | |
| 700 | 1 | |a Beretta, Enrico |e verfasserin |4 aut | |
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