Annual decline in arterial blood oxygen predicts development of chronic respiratory failure in COPD with mild hypoxaemia : A 6-year follow-up study
© 2018 Asian Pacific Society of Respirology..
BACKGROUND AND OBJECTIVE: Chronic respiratory failure (CRF) with hypoxaemia is an important pathophysiology in patients with chronic obstructive pulmonary disease (COPD), and existing mild hypoxaemia may be a sign of future CRF development. However, little is known about the trajectory of partial arterial pressure of oxygen (PaO2 ) decline in patients with COPD. We assessed decline in PaO2 and the impact of short-term reductions in PaO2 to predict future decline in PaO2.
METHODS: A total of 172 outpatients with COPD from a prospective cohort study were enrolled. Pulmonary function tests and arterial blood gas (ABG) analyses were conducted at baseline and 1 year after enrolment and changes in PaO2 (ΔPaO2 ) and other parameters were calculated. Survival and incidence of CRF (as assessed by prescription of long-term home oxygen therapy) were monitored for 6 years.
RESULTS: A total of 164 patients completed the observation period and 101 patients had mild hypoxaemia (PaO2 < 80 Torr) at baseline. No patients with normal PaO2 (≥80 Torr) developed CRF, and 10 patients with mild hypoxaemia developed CRF in 6 years. Baseline airflow limitation and diffusion capacity were significantly associated with development of CRF. Receiver-operating characteristic curve analysis showed that ΔPaO2 of -3.05 Torr/year is a useful cut-off value to predict development of CRF in 6 years (hazard ratio (HR): 12.6, 95% CI: 3.48-58.73, P < 0.0001).
CONCLUSION: Patients with COPD and mild hypoxaemia may benefit from repeat ABG after 1 year. Although PaO2 trajectories widely varied, significant annual changes in PaO2 of at least -3.0 Torr/year were predictive of CRF development.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
Respirology (Carlton, Vic.) - 24(2019), 3 vom: 03. März, Seite 262-269 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Uemasu, Kiyoshi [VerfasserIn] |
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| Links: |
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| Themen: |
Arterial blood gas |
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| Anmerkungen: |
Date Completed 03.03.2020 Date Revised 03.03.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/resp.13402 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM288673344 |
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| 100 | 1 | |a Uemasu, Kiyoshi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Annual decline in arterial blood oxygen predicts development of chronic respiratory failure in COPD with mild hypoxaemia |b A 6-year follow-up study |
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| 500 | |a Date Completed 03.03.2020 | ||
| 500 | |a Date Revised 03.03.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2018 Asian Pacific Society of Respirology. | ||
| 520 | |a BACKGROUND AND OBJECTIVE: Chronic respiratory failure (CRF) with hypoxaemia is an important pathophysiology in patients with chronic obstructive pulmonary disease (COPD), and existing mild hypoxaemia may be a sign of future CRF development. However, little is known about the trajectory of partial arterial pressure of oxygen (PaO2 ) decline in patients with COPD. We assessed decline in PaO2 and the impact of short-term reductions in PaO2 to predict future decline in PaO2 | ||
| 520 | |a METHODS: A total of 172 outpatients with COPD from a prospective cohort study were enrolled. Pulmonary function tests and arterial blood gas (ABG) analyses were conducted at baseline and 1 year after enrolment and changes in PaO2 (ΔPaO2 ) and other parameters were calculated. Survival and incidence of CRF (as assessed by prescription of long-term home oxygen therapy) were monitored for 6 years | ||
| 520 | |a RESULTS: A total of 164 patients completed the observation period and 101 patients had mild hypoxaemia (PaO2 < 80 Torr) at baseline. No patients with normal PaO2 (≥80 Torr) developed CRF, and 10 patients with mild hypoxaemia developed CRF in 6 years. Baseline airflow limitation and diffusion capacity were significantly associated with development of CRF. Receiver-operating characteristic curve analysis showed that ΔPaO2 of -3.05 Torr/year is a useful cut-off value to predict development of CRF in 6 years (hazard ratio (HR): 12.6, 95% CI: 3.48-58.73, P < 0.0001) | ||
| 520 | |a CONCLUSION: Patients with COPD and mild hypoxaemia may benefit from repeat ABG after 1 year. Although PaO2 trajectories widely varied, significant annual changes in PaO2 of at least -3.0 Torr/year were predictive of CRF development | ||
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| 650 | 4 | |a chronic obstructive pulmonary disease | |
| 650 | 4 | |a emphysema | |
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| 700 | 1 | |a Muro, Shigeo |e verfasserin |4 aut | |
| 700 | 1 | |a Sato, Atsuyasu |e verfasserin |4 aut | |
| 700 | 1 | |a Tanabe, Naoya |e verfasserin |4 aut | |
| 700 | 1 | |a Hasegawa, Koichi |e verfasserin |4 aut | |
| 700 | 1 | |a Hamakawa, Yoko |e verfasserin |4 aut | |
| 700 | 1 | |a Mizutani, Tatsushi |e verfasserin |4 aut | |
| 700 | 1 | |a Fuseya, Yoshinori |e verfasserin |4 aut | |
| 700 | 1 | |a Tanimura, Kazuya |e verfasserin |4 aut | |
| 700 | 1 | |a Takahashi, Tamaki |e verfasserin |4 aut | |
| 700 | 1 | |a Hirai, Toyohiro |e verfasserin |4 aut | |
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