Diffusion Tensor Imaging of the Calf Muscles in Subjects With and Without Diabetes Mellitus
© 2018 International Society for Magnetic Resonance in Medicine..
BACKGROUND: Diffusion tensor imaging (DTI) has been used to characterize calf skeletal muscle architecture.
PURPOSE: To assess the diffusional properties of the calf muscles of subjects with and without diabetes, at rest and during isometric plantarflexion exercise.
STUDY TYPE: Prospective.
SUBJECTS: Twenty-six subjects in two groups: 13 healthy and 13 subjects with type 2 diabetes (DM); each group consisted of seven females and six males.
FIELD STRENGTH/SEQUENCE: 3T/2D single-shot spin echo planar imaging.
ASSESSMENT: Fractional anisotropy (FA), mean diffusivity (MD), diffusion eigenvalues, and fiber tracking indices were obtained from the medial gastrocnemius (MG), lateral gastrocnemius (LG), and soleus (SOL) muscles of the calf at rest and during isometric plantarflexion exercise.
STATISTICAL TESTS: We used a combination of nonparametric (Wilcoxon) and parametric (t-test) statistical assessments.
RESULTS: The medial gastrocnemius muscle had more indices with significant differences between the two groups (six indices with P < 0.05) than did the lateral gastrocnemius (three indices with P < 0.05) and soleus muscles (only one index with P < 0.05). While the healthy group showed elevated MD values from rest to exercise (MG = 5.83%, LG = 13.45%, and SOL = 11.68%), the diabetic MD showed higher increases (MG = 19.74%, LG = 29.31%, and SOL = 20.84%) that were different between groups (MG: P = 0.009, LG: P = 0.037, and SOL: P = 0.049).
DATA CONCLUSION: Our results indicate considerable diffusional changes between healthy subjects and subjects with diabetes at rest and during isometric plantarflexion exercise in the calf muscles. The medial gastrocnemius muscle displayed the most diffusion sensitivity to diabetes-related microstructural changes.
LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:1285-1295.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:49 |
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| Enthalten in: |
Journal of magnetic resonance imaging : JMRI - 49(2019), 5 vom: 30. Mai, Seite 1285-1295 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Edalati, Masoud [VerfasserIn] |
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| Anmerkungen: |
Date Completed 13.08.2020 Date Revised 09.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/jmri.26286 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM288667980 |
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| 245 | 1 | 0 | |a Diffusion Tensor Imaging of the Calf Muscles in Subjects With and Without Diabetes Mellitus |
| 264 | 1 | |c 2019 | |
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| 500 | |a Date Completed 13.08.2020 | ||
| 500 | |a Date Revised 09.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2018 International Society for Magnetic Resonance in Medicine. | ||
| 520 | |a BACKGROUND: Diffusion tensor imaging (DTI) has been used to characterize calf skeletal muscle architecture | ||
| 520 | |a PURPOSE: To assess the diffusional properties of the calf muscles of subjects with and without diabetes, at rest and during isometric plantarflexion exercise | ||
| 520 | |a STUDY TYPE: Prospective | ||
| 520 | |a SUBJECTS: Twenty-six subjects in two groups: 13 healthy and 13 subjects with type 2 diabetes (DM); each group consisted of seven females and six males | ||
| 520 | |a FIELD STRENGTH/SEQUENCE: 3T/2D single-shot spin echo planar imaging | ||
| 520 | |a ASSESSMENT: Fractional anisotropy (FA), mean diffusivity (MD), diffusion eigenvalues, and fiber tracking indices were obtained from the medial gastrocnemius (MG), lateral gastrocnemius (LG), and soleus (SOL) muscles of the calf at rest and during isometric plantarflexion exercise | ||
| 520 | |a STATISTICAL TESTS: We used a combination of nonparametric (Wilcoxon) and parametric (t-test) statistical assessments | ||
| 520 | |a RESULTS: The medial gastrocnemius muscle had more indices with significant differences between the two groups (six indices with P < 0.05) than did the lateral gastrocnemius (three indices with P < 0.05) and soleus muscles (only one index with P < 0.05). While the healthy group showed elevated MD values from rest to exercise (MG = 5.83%, LG = 13.45%, and SOL = 11.68%), the diabetic MD showed higher increases (MG = 19.74%, LG = 29.31%, and SOL = 20.84%) that were different between groups (MG: P = 0.009, LG: P = 0.037, and SOL: P = 0.049) | ||
| 520 | |a DATA CONCLUSION: Our results indicate considerable diffusional changes between healthy subjects and subjects with diabetes at rest and during isometric plantarflexion exercise in the calf muscles. The medial gastrocnemius muscle displayed the most diffusion sensitivity to diabetes-related microstructural changes | ||
| 520 | |a LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:1285-1295 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 700 | 1 | |a Hastings, Mary K |e verfasserin |4 aut | |
| 700 | 1 | |a Sorensen, Christopher J |e verfasserin |4 aut | |
| 700 | 1 | |a Zayed, Mohamed |e verfasserin |4 aut | |
| 700 | 1 | |a Mueller, Michael J |e verfasserin |4 aut | |
| 700 | 1 | |a Hildebolt, Charles F |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Jie |e verfasserin |4 aut | |
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