Th17 and Treg lymphocytes in obesity and Type 2 diabetic patients
Copyright © 2018. Published by Elsevier Inc..
Assumption that the pathogenesis of obesity-associated type 2 diabetes (T2DM) encompasses inflammation and autoimmune aspects is increasingly recognized. In the state of obesity and T2DM, the imbalance of T helper 17 (Th17) cells and regulatory T (Treg) cells are observed. These alterations reflect a loss of T cell homeostasis, which may contribute to tissue and systemic inflammation and immunity in T2DM. In this review we will discuss the accumulating data supporting the concept that Th17/Treg mediated immune responses are present in obesity-related T2DM pathogenesis, and provide evidences that restoration of Th17/Treg imbalance may be a possible therapeutic avenue for the prevention and treatment of T2DM and its complications.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:197 |
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| Enthalten in: |
Clinical immunology (Orlando, Fla.) - 197(2018) vom: 01. Dez., Seite 77-85 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Mei [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 07.10.2019 Date Revised 07.10.2019 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.clim.2018.09.005 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM288555813 |
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| 500 | |a Date Revised 07.10.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2018. Published by Elsevier Inc. | ||
| 520 | |a Assumption that the pathogenesis of obesity-associated type 2 diabetes (T2DM) encompasses inflammation and autoimmune aspects is increasingly recognized. In the state of obesity and T2DM, the imbalance of T helper 17 (Th17) cells and regulatory T (Treg) cells are observed. These alterations reflect a loss of T cell homeostasis, which may contribute to tissue and systemic inflammation and immunity in T2DM. In this review we will discuss the accumulating data supporting the concept that Th17/Treg mediated immune responses are present in obesity-related T2DM pathogenesis, and provide evidences that restoration of Th17/Treg imbalance may be a possible therapeutic avenue for the prevention and treatment of T2DM and its complications | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Obesity | |
| 650 | 4 | |a Th17 cell | |
| 650 | 4 | |a Treg cell | |
| 650 | 4 | |a Type 2 diabetes | |
| 700 | 1 | |a Chen, Fuqiong |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jingli |e verfasserin |4 aut | |
| 700 | 1 | |a Zeng, Zhixuan |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Qin |e verfasserin |4 aut | |
| 700 | 1 | |a Shao, Shiying |e verfasserin |4 aut | |
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