Diagnosis and management of NSAID-Exacerbated Respiratory Disease (N-ERD)-a EAACI position paper
© 2018 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd..
NSAID-exacerbated respiratory disease (N-ERD) is a chronic eosinophilic, inflammatory disorder of the respiratory tract occurring in patients with asthma and/or chronic rhinosinusitis with nasal polyps (CRSwNP), symptoms of which are exacerbated by NSAIDs, including aspirin. Despite some progress in understanding of the pathophysiology of the syndrome, which affects 1/10 of patients with asthma and rhinosinusitis, it remains a diagnostic and therapeutic challenge. In order to provide evidence-based recommendations for the diagnosis and management of N-ERD, a panel of international experts was called by the EAACI Asthma Section. The document summarizes current knowledge on the pathophysiology and clinical presentation of N-ERD pointing at significant heterogeneity of this syndrome. Critically evaluating the usefulness of diagnostic tools available, the paper offers practical algorithm for the diagnosis of N-ERD. Recommendations for the most effective management of a patient with N-ERD stressing the potential high morbidity and severity of the underlying asthma and rhinosinusitis are discussed and proposed. Newly described sub-phenotypes and emerging sub-endotypes of N-ERD are potentially relevant for new and more specific (eg, biological) treatment modalities. Finally, the document defines major gaps in our knowledge on N-ERD and unmet needs, which should be addressed in the future.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:74 |
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| Enthalten in: |
Allergy - 74(2019), 1 vom: 01. Jan., Seite 28-39 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kowalski, Marek L [VerfasserIn] |
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| Links: |
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| Themen: |
AERD |
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| Anmerkungen: |
Date Completed 20.03.2020 Date Revised 20.03.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/all.13599 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a NSAID-exacerbated respiratory disease (N-ERD) is a chronic eosinophilic, inflammatory disorder of the respiratory tract occurring in patients with asthma and/or chronic rhinosinusitis with nasal polyps (CRSwNP), symptoms of which are exacerbated by NSAIDs, including aspirin. Despite some progress in understanding of the pathophysiology of the syndrome, which affects 1/10 of patients with asthma and rhinosinusitis, it remains a diagnostic and therapeutic challenge. In order to provide evidence-based recommendations for the diagnosis and management of N-ERD, a panel of international experts was called by the EAACI Asthma Section. The document summarizes current knowledge on the pathophysiology and clinical presentation of N-ERD pointing at significant heterogeneity of this syndrome. Critically evaluating the usefulness of diagnostic tools available, the paper offers practical algorithm for the diagnosis of N-ERD. Recommendations for the most effective management of a patient with N-ERD stressing the potential high morbidity and severity of the underlying asthma and rhinosinusitis are discussed and proposed. Newly described sub-phenotypes and emerging sub-endotypes of N-ERD are potentially relevant for new and more specific (eg, biological) treatment modalities. Finally, the document defines major gaps in our knowledge on N-ERD and unmet needs, which should be addressed in the future | ||
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| 700 | 1 | |a Blanca, Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Bochenek, Grażyna |e verfasserin |4 aut | |
| 700 | 1 | |a Bonini, Matteo |e verfasserin |4 aut | |
| 700 | 1 | |a Heffler, Enrico |e verfasserin |4 aut | |
| 700 | 1 | |a Klimek, Ludger |e verfasserin |4 aut | |
| 700 | 1 | |a Laidlaw, Tanya M |e verfasserin |4 aut | |
| 700 | 1 | |a Mullol, Joaquim |e verfasserin |4 aut | |
| 700 | 1 | |a Niżankowska-Mogilnicka, Ewa |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Hae-Sim |e verfasserin |4 aut | |
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| 700 | 1 | |a Sanchez-Borges, Mario |e verfasserin |4 aut | |
| 700 | 1 | |a Sanchez-Garcia, Silvia |e verfasserin |4 aut | |
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| 700 | 1 | |a Wardzyńska, Aleksandra |e verfasserin |4 aut | |
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