Kaposi's Sarcoma Herpesvirus-associated Inflammatory Cytokine Syndrome (KICS) Improved by Antiretroviral Therapy in an HIV-infected Patient
We report a case of a 63-year-old HIV-positive Japanese male with a CD4 cell count of 127/μL who was admitted to our hospital because of suspected malignant lymphoma. Initial blood tests revealed anemia, thrombocytopenia, hypoalbuminemia, and hypergammaglobulinemia. Imaging tests revealed a lung nodule, bilateral pleural effusion, hepatosplenomegaly and generalized lymphadenopathy. No evidence of malignant lymphoma or multicentric Castleman's disease was noted on biopsy specimens; however, Kaposi sarcoma-associated herpesvirus (KSHV)-encoded latency-associated nuclear antigen-1-positive cells were observed as well as an elevated interleukin (IL)-6, IL-10 and KSHV viral load. He fulfilled the novel diagnostic criteria for KSHV-associated inflammatory cytokine syndrome (KICS). After initiating antiretroviral therapy, his symptoms and radiological abnormalities drastically improved. After 1-year follow-up, his HIV was well controlled without any relapsing symptoms.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:90 |
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| Enthalten in: |
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases - 90(2016), 4 vom: 16. Juli, Seite 512-7 |
| Sprache: |
Japanisch |
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| Beteiligte Personen: |
Nishiki, Shingo [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 17.12.2018 Date Revised 17.12.2018 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM288491599 |
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| 245 | 1 | 0 | |a Kaposi's Sarcoma Herpesvirus-associated Inflammatory Cytokine Syndrome (KICS) Improved by Antiretroviral Therapy in an HIV-infected Patient |
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| 500 | |a Date Completed 17.12.2018 | ||
| 500 | |a Date Revised 17.12.2018 | ||
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a We report a case of a 63-year-old HIV-positive Japanese male with a CD4 cell count of 127/μL who was admitted to our hospital because of suspected malignant lymphoma. Initial blood tests revealed anemia, thrombocytopenia, hypoalbuminemia, and hypergammaglobulinemia. Imaging tests revealed a lung nodule, bilateral pleural effusion, hepatosplenomegaly and generalized lymphadenopathy. No evidence of malignant lymphoma or multicentric Castleman's disease was noted on biopsy specimens; however, Kaposi sarcoma-associated herpesvirus (KSHV)-encoded latency-associated nuclear antigen-1-positive cells were observed as well as an elevated interleukin (IL)-6, IL-10 and KSHV viral load. He fulfilled the novel diagnostic criteria for KSHV-associated inflammatory cytokine syndrome (KICS). After initiating antiretroviral therapy, his symptoms and radiological abnormalities drastically improved. After 1-year follow-up, his HIV was well controlled without any relapsing symptoms | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Anti-Retroviral Agents |2 NLM | |
| 650 | 7 | |a Cytokines |2 NLM | |
| 700 | 1 | |a Yanagisawa, Naoki |e verfasserin |4 aut | |
| 700 | 1 | |a Sasaki, Shugo |e verfasserin |4 aut | |
| 700 | 1 | |a Sekiya, Ryoko |e verfasserin |4 aut | |
| 700 | 1 | |a Sekiya, Noritaka |e verfasserin |4 aut | |
| 700 | 1 | |a Suganuma, Akihiko |e verfasserin |4 aut | |
| 700 | 1 | |a Ajisawa, Atsushi |e verfasserin |4 aut | |
| 700 | 1 | |a Akifumi, Imamura |e verfasserin |4 aut | |
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