Sex differences in functional and molecular neuroimaging biomarkers of Alzheimer's disease in cognitively normal older adults with subjective memory complaints
Copyright © 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved..
INTRODUCTION: Observational multimodal neuroimaging studies indicate sex differences in Alzheimer's disease pathophysiological markers.
METHODS: Positron emission tomography brain amyloid load, neurodegeneration (hippocampus and basal forebrain volumes adjusted to total intracranial volume, cortical thickness, and 2-deoxy-2-[fluorine-18]fluoro-D-glucose-positron emission tomography metabolism), and brain resting-state functional connectivity were analyzed in 318 cognitively intact older adults from the INSIGHT-preAD cohort (female n = 201, male n = 117). A linear mixed-effects model was performed to investigate sex effects and sex∗apolipoprotein E genotype interaction on each marker as well as sex∗amyloid group interaction for non-amyloid markers.
RESULTS: Men compared with women showed higher anterior cingulate cortex amyloid load (P = .009), glucose hypometabolism in the precuneus (P = .027), posterior cingulate (P < .001) and inferior parietal (P = .043) cortices, and lower resting-state functional connectivity in the default mode network (P = .024). No brain volumetric markers showed differences between men and women. Sex∗apolipoprotein E genotype and sex∗amyloid status interactions were not significant.
DISCUSSION: Our findings suggest that cognitively intact older men compared with women have higher resilience to pathophysiological processes of Alzheimer's disease.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Alzheimer's & dementia : the journal of the Alzheimer's Association - 14(2018), 9 vom: 06. Sept., Seite 1204-1215 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cavedo, Enrica [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 27.09.2019 Date Revised 09.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jalz.2018.05.014 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM288384083 |
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| 245 | 1 | 0 | |a Sex differences in functional and molecular neuroimaging biomarkers of Alzheimer's disease in cognitively normal older adults with subjective memory complaints |
| 264 | 1 | |c 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 27.09.2019 | ||
| 500 | |a Date Revised 09.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a INTRODUCTION: Observational multimodal neuroimaging studies indicate sex differences in Alzheimer's disease pathophysiological markers | ||
| 520 | |a METHODS: Positron emission tomography brain amyloid load, neurodegeneration (hippocampus and basal forebrain volumes adjusted to total intracranial volume, cortical thickness, and 2-deoxy-2-[fluorine-18]fluoro-D-glucose-positron emission tomography metabolism), and brain resting-state functional connectivity were analyzed in 318 cognitively intact older adults from the INSIGHT-preAD cohort (female n = 201, male n = 117). A linear mixed-effects model was performed to investigate sex effects and sex∗apolipoprotein E genotype interaction on each marker as well as sex∗amyloid group interaction for non-amyloid markers | ||
| 520 | |a RESULTS: Men compared with women showed higher anterior cingulate cortex amyloid load (P = .009), glucose hypometabolism in the precuneus (P = .027), posterior cingulate (P < .001) and inferior parietal (P = .043) cortices, and lower resting-state functional connectivity in the default mode network (P = .024). No brain volumetric markers showed differences between men and women. Sex∗apolipoprotein E genotype and sex∗amyloid status interactions were not significant | ||
| 520 | |a DISCUSSION: Our findings suggest that cognitively intact older men compared with women have higher resilience to pathophysiological processes of Alzheimer's disease | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a APOE | |
| 650 | 4 | |a Aging | |
| 650 | 4 | |a Alzheimer's disease | |
| 650 | 4 | |a Amyloid | |
| 650 | 4 | |a Basal forebrain | |
| 650 | 4 | |a Cognitively intact older individuals | |
| 650 | 4 | |a Cortical thickness | |
| 650 | 4 | |a FDG-PET | |
| 650 | 4 | |a Hippocampus | |
| 650 | 4 | |a Metabolism | |
| 650 | 4 | |a Sex | |
| 650 | 7 | |a Amyloid |2 NLM | |
| 650 | 7 | |a Apolipoproteins E |2 NLM | |
| 650 | 7 | |a Glucose |2 NLM | |
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| 700 | 1 | |a Grothe, Michel J |e verfasserin |4 aut | |
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| 700 | 1 | |a Hampel, Harald |e verfasserin |4 aut | |
| 700 | 0 | |a INSIGHT-preAD Study Group |e verfasserin |4 aut | |
| 700 | 0 | |a Alzheimer Precision Medicine Initiative (APMI) |e verfasserin |4 aut | |
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