Determinants of methicillin-resistant Staphylococcus aureus (MRSA) prevalence in the Asia-Pacific region : A systematic review and meta-analysis
Copyright © 2018 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved..
OBJECTIVES: Published literature on methicillin-resistant Staphylococcus aureus (MRSA) in the Asia-Pacific region was reviewed to document the prevalence of MRSA in the region and to examine the impact of variability in study design on the reported MRSA prevalence data.
METHODS: This review included studies reporting MRSA prevalence between 2000 and 2016. Studies were excluded if they did not contain complete information on antimicrobial susceptibility testing (AST) methods. Primary outcomes were the proportion of MRSA among S. aureus isolates (resistance proportion) or among individual samples (prevalence).
RESULTS: A total of 229 studies in 19 countries/territories were included in the study. There was substantial heterogeneity in both outcomes (resistance proportion, I2=99.59%; prevalence, I2=99.83%), precluding pooled averages, and meta-regression analyses revealed that these variations were explained by country income status and participant characteristics but not by methodological differences in AST. Also, no significant secular changes in MRSA prevalence or resistance proportions in Asia-Pacific were found.
CONCLUSION: The resistance proportions and prevalence of MRSA infections in Asia-Pacific are comparable with those reported in other regions with no significant secular changes in the past decade. Country income status and characteristics of the sample population explained more variation in the reported resistance proportions and prevalence of MRSA than methodological differences in AST across locations in the region.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
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| Enthalten in: |
Journal of global antimicrobial resistance - 16(2019) vom: 25. März, Seite 17-27 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lim, Wey Wen [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-Bacterial Agents |
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| Anmerkungen: |
Date Completed 25.03.2020 Date Revised 25.03.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jgar.2018.08.014 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM287833801 |
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| 100 | 1 | |a Lim, Wey Wen |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Determinants of methicillin-resistant Staphylococcus aureus (MRSA) prevalence in the Asia-Pacific region |b A systematic review and meta-analysis |
| 264 | 1 | |c 2019 | |
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| 500 | |a Date Completed 25.03.2020 | ||
| 500 | |a Date Revised 25.03.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2018 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved. | ||
| 520 | |a OBJECTIVES: Published literature on methicillin-resistant Staphylococcus aureus (MRSA) in the Asia-Pacific region was reviewed to document the prevalence of MRSA in the region and to examine the impact of variability in study design on the reported MRSA prevalence data | ||
| 520 | |a METHODS: This review included studies reporting MRSA prevalence between 2000 and 2016. Studies were excluded if they did not contain complete information on antimicrobial susceptibility testing (AST) methods. Primary outcomes were the proportion of MRSA among S. aureus isolates (resistance proportion) or among individual samples (prevalence) | ||
| 520 | |a RESULTS: A total of 229 studies in 19 countries/territories were included in the study. There was substantial heterogeneity in both outcomes (resistance proportion, I2=99.59%; prevalence, I2=99.83%), precluding pooled averages, and meta-regression analyses revealed that these variations were explained by country income status and participant characteristics but not by methodological differences in AST. Also, no significant secular changes in MRSA prevalence or resistance proportions in Asia-Pacific were found | ||
| 520 | |a CONCLUSION: The resistance proportions and prevalence of MRSA infections in Asia-Pacific are comparable with those reported in other regions with no significant secular changes in the past decade. Country income status and characteristics of the sample population explained more variation in the reported resistance proportions and prevalence of MRSA than methodological differences in AST across locations in the region | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a Antimicrobial resistance | |
| 650 | 4 | |a Asia-Pacific | |
| 650 | 4 | |a MRSA | |
| 650 | 4 | |a Methicillin resistance | |
| 650 | 4 | |a Staphylococcus aureus | |
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| 700 | 1 | |a Bond, Helen S |e verfasserin |4 aut | |
| 700 | 1 | |a Wong, Jessica Y |e verfasserin |4 aut | |
| 700 | 1 | |a Ni, Kaiwen |e verfasserin |4 aut | |
| 700 | 1 | |a Seto, Wing Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Jit, Mark |e verfasserin |4 aut | |
| 700 | 1 | |a Cowling, Benjamin J |e verfasserin |4 aut | |
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