Early or late pregnancy loss and development of clinical cardiovascular disease risk factors : a prospective cohort study
© 2018 Royal College of Obstetricians and Gynaecologists..
OBJECTIVE: To assess the association between the outcome of a woman's first pregnancy and risk of clinical cardiovascular disease risk factors.
DESIGN: Prospective cohort study.
SETTING AND POPULATION: Nurses' Health Study II.
METHODS: Multivariable-adjusted Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between first pregnancy outcome and hypertension, type 2 diabetes, and hypercholesterolemia.
MAIN OUTCOME MEASURES: Hypertension, type 2 diabetes, and hypercholesterolemia.
RESULTS: Compared to women who reported a singleton live first birth, women with early spontaneous abortion (<12 weeks) had a greater rate of type 2 diabetes (HR: 1.20; 95% CI: 1.07-1.34) and hypercholesterolemia (HR: 1.06; 95% CI: 1.02-1.10), and a marginally increased rate of hypertension (HR: 1.05, 95% CI: 1.00-1.11). Late spontaneous abortion (12-19 weeks) was associated with an increased rate of type 2 diabetes (HR: 1.38; 95% CI: 1.14-1.65), hypercholesterolemia (HR: 1.11; 95% CI: 1.03-1.19), and hypertension (HR: 1.15; 95% CI: 1.05-1.25). The rates of type 2 diabetes (HR: 1.45; 95% CI: 1.13-1.87) and hypertension (HR: 1.15; 95% CI: 1.01-1.30) were higher in women who delivered stillbirth. In contrast, women whose first pregnancy ended in an induced abortion had lower rates of hypertension (HR: 0.87; 95% CI: 0.84-0.91) and type 2 diabetes (HR: 0.89; 95% CI: 0.79-0.99) than women with a singleton live birth.
CONCLUSIONS: Several types of pregnancy loss were associated with an increased rate of hypertension, type 2 diabetes, and hypercholesterolemia, which may provide novel insight into the pathways through which pregnancy outcomes and CVD are linked.
TWEETABLE ABSTRACT: Pregnancy loss is associated with later maternal risk of hypertension, type 2 diabetes, and hypercholesterolemia.
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:126 |
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| Enthalten in: |
BJOG : an international journal of obstetrics and gynaecology - 126(2019), 1 vom: 02. Jan., Seite 33-42 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Horn, J [VerfasserIn] |
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| Links: |
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| Themen: |
Cardiovascular diseases |
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| Anmerkungen: |
Date Completed 11.03.2019 Date Revised 30.03.2022 published: Print-Electronic CommentIn: BJOG. 2019 Jan;126(1):43. - PMID 30387547 Citation Status MEDLINE |
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| doi: |
10.1111/1471-0528.15452 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM287823997 |
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| 100 | 1 | |a Horn, J |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Early or late pregnancy loss and development of clinical cardiovascular disease risk factors |b a prospective cohort study |
| 264 | 1 | |c 2019 | |
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| 500 | |a Date Completed 11.03.2019 | ||
| 500 | |a Date Revised 30.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: BJOG. 2019 Jan;126(1):43. - PMID 30387547 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2018 Royal College of Obstetricians and Gynaecologists. | ||
| 520 | |a OBJECTIVE: To assess the association between the outcome of a woman's first pregnancy and risk of clinical cardiovascular disease risk factors | ||
| 520 | |a DESIGN: Prospective cohort study | ||
| 520 | |a SETTING AND POPULATION: Nurses' Health Study II | ||
| 520 | |a METHODS: Multivariable-adjusted Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between first pregnancy outcome and hypertension, type 2 diabetes, and hypercholesterolemia | ||
| 520 | |a MAIN OUTCOME MEASURES: Hypertension, type 2 diabetes, and hypercholesterolemia | ||
| 520 | |a RESULTS: Compared to women who reported a singleton live first birth, women with early spontaneous abortion (<12 weeks) had a greater rate of type 2 diabetes (HR: 1.20; 95% CI: 1.07-1.34) and hypercholesterolemia (HR: 1.06; 95% CI: 1.02-1.10), and a marginally increased rate of hypertension (HR: 1.05, 95% CI: 1.00-1.11). Late spontaneous abortion (12-19 weeks) was associated with an increased rate of type 2 diabetes (HR: 1.38; 95% CI: 1.14-1.65), hypercholesterolemia (HR: 1.11; 95% CI: 1.03-1.19), and hypertension (HR: 1.15; 95% CI: 1.05-1.25). The rates of type 2 diabetes (HR: 1.45; 95% CI: 1.13-1.87) and hypertension (HR: 1.15; 95% CI: 1.01-1.30) were higher in women who delivered stillbirth. In contrast, women whose first pregnancy ended in an induced abortion had lower rates of hypertension (HR: 0.87; 95% CI: 0.84-0.91) and type 2 diabetes (HR: 0.89; 95% CI: 0.79-0.99) than women with a singleton live birth | ||
| 520 | |a CONCLUSIONS: Several types of pregnancy loss were associated with an increased rate of hypertension, type 2 diabetes, and hypercholesterolemia, which may provide novel insight into the pathways through which pregnancy outcomes and CVD are linked | ||
| 520 | |a TWEETABLE ABSTRACT: Pregnancy loss is associated with later maternal risk of hypertension, type 2 diabetes, and hypercholesterolemia | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cardiovascular diseases | |
| 650 | 4 | |a diabetes mellitus | |
| 650 | 4 | |a hypercholesterolemia | |
| 650 | 4 | |a hypertension | |
| 650 | 4 | |a pregnancy loss | |
| 650 | 4 | |a risk factors | |
| 650 | 4 | |a spontaneous abortion | |
| 650 | 4 | |a stillbirth | |
| 650 | 4 | |a women's health | |
| 700 | 1 | |a Tanz, L J |e verfasserin |4 aut | |
| 700 | 1 | |a Stuart, J J |e verfasserin |4 aut | |
| 700 | 1 | |a Markovitz, A R |e verfasserin |4 aut | |
| 700 | 1 | |a Skurnik, G |e verfasserin |4 aut | |
| 700 | 1 | |a Rimm, E B |e verfasserin |4 aut | |
| 700 | 1 | |a Missmer, S A |e verfasserin |4 aut | |
| 700 | 1 | |a Rich-Edwards, J W |e verfasserin |4 aut | |
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