Characteristics of the Renin-Angiotensin-Aldosterone System in Carriers of Polymorphic Variants of the VDR Gene With Arterial Hypertension and Obesity
AIM: to study the renin-angiotensin-aldosterone-system (RAAS) in patients with polymorphic variants of the vitamin D receptor gene (VDR), arterial hypertension (AH) and obesity.
MATERIALS AND METHODS: We included in this study 98 patients with stage II-III AH and obesity (33 men, 65 women, mean age 61.1±9.9 years and BMI 43.3±5.0 kg/m2). The VDR gene study included genotypes TaqI, BsmI, FokI. After identification of TaqI, BsmI, FokI VDR gene sites we carried out measurements of levels of RAAS markers.
RESULTS: We revealed an associative relationship between the presence of allele G of the BsmI site, C/C homozygosity of FokI site of VDR gene and presence of AH in patients with obesity. An increase of renin level was noted only in the homozygous T/T genotype of FokI, no differences in the concentration of aldosterone and angiotensin were detected between any of the studied genotypes.
CONCLUSION: Polymorphic alleles and genotypes of the VDR gene can be used as predictors of AH development in obese patients with subsequent characterization of the state of the RAAS system.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2018 |
|---|---|
| Enthalten in: |
Kardiologiia - (2018), 8 vom: 01. Aug., Seite 45-49 |
| Sprache: |
Russisch |
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| Beteiligte Personen: |
Sentsova, T B [VerfasserIn] |
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| Themen: |
Arterial hypertension |
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| Anmerkungen: |
Date Completed 16.05.2019 Date Revised 16.05.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM287695301 |
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| 245 | 1 | 0 | |a Characteristics of the Renin-Angiotensin-Aldosterone System in Carriers of Polymorphic Variants of the VDR Gene With Arterial Hypertension and Obesity |
| 264 | 1 | |c 2018 | |
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| 500 | |a Date Completed 16.05.2019 | ||
| 500 | |a Date Revised 16.05.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a AIM: to study the renin-angiotensin-aldosterone-system (RAAS) in patients with polymorphic variants of the vitamin D receptor gene (VDR), arterial hypertension (AH) and obesity | ||
| 520 | |a MATERIALS AND METHODS: We included in this study 98 patients with stage II-III AH and obesity (33 men, 65 women, mean age 61.1±9.9 years and BMI 43.3±5.0 kg/m2). The VDR gene study included genotypes TaqI, BsmI, FokI. After identification of TaqI, BsmI, FokI VDR gene sites we carried out measurements of levels of RAAS markers | ||
| 520 | |a RESULTS: We revealed an associative relationship between the presence of allele G of the BsmI site, C/C homozygosity of FokI site of VDR gene and presence of AH in patients with obesity. An increase of renin level was noted only in the homozygous T/T genotype of FokI, no differences in the concentration of aldosterone and angiotensin were detected between any of the studied genotypes | ||
| 520 | |a CONCLUSION: Polymorphic alleles and genotypes of the VDR gene can be used as predictors of AH development in obese patients with subsequent characterization of the state of the RAAS system | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a VDR gene | |
| 650 | 4 | |a arterial hypertension | |
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| 650 | 4 | |a renin-angiotensin-aldosterone system | |
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| 650 | 7 | |a VDR protein, human |2 NLM | |
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| 700 | 1 | |a Chernyak, O O |e verfasserin |4 aut | |
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| 700 | 1 | |a Zaletova, T S |e verfasserin |4 aut | |
| 700 | 1 | |a Gioeva, Z M |e verfasserin |4 aut | |
| 700 | 1 | |a Bogdanova, A A |e verfasserin |4 aut | |
| 700 | 1 | |a Donnikov, A E |e verfasserin |4 aut | |
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