Validation of the MB-LATER score for prediction of late recurrence after catheter-ablation of atrial fibrillation
Copyright © 2018. Published by Elsevier B.V..
BACKGROUND: Reliable identification of atrial fibrillation (AF) patients more likely to be AF-free long-term post-single catheter ablation (CA) would facilitate appropriate risk communication to patients. We validated the recently proposed MB-LATER score for prediction of late recurrences of AF (LRAF) post-CA.
METHODS: Patients who underwent CA for symptomatic AF refractory to ≥1 antiarrhythmic drugs at the Johns Hopkins Hospital, Baltimore, between March 2003 and December 2015, for whom ≥1-year post-CA follow-up data were available, were enrolled.
RESULTS: Of 226 patients (median age 58.5 years [IQR: 52.0-65.0], 163 males [72.1%], 142 [62.8%] with paroxysmal AF), LRAF occurred in 133 patients (58.8%) during a median 2-year follow-up (IQR: 1.1-4.1). The mean MB-LATER score was significantly higher in patients with versus those without LRAF (2.4 ± 1.2 vs. 1.9 ± 1.3, p = 0.002) and showed modest but significant predictive ability for LRAF (AUC: 0.62 [95% CI: 0.54-0.69], p = 0.003). A score cut-off value of >2 showed the best predictive ability for LRAF (70.4% [61.5-77.9]), with modest sensitivity (42.9% [34.3-51.7]) and specificity (74.2% [64.1-82.7]). Kaplan-Meyer survival free from AF was significantly better for patients with a MB-LATER score of ≤2 than for those with a score of >2 (log-rank p = 0.005).
CONCLUSION: In our study, the MB-LATER score showed a significant but modest predictive ability for LRAF post-AF ablation. Further prospective validation is needed to better define the potential role of the MB-LATER score in patient selection and treatment decision-making post-AF ablation.
| Errataetall: |
CommentIn: Int J Cardiol. 2019 Feb 1;276:154-155. - PMID 30514578 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:276 |
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| Enthalten in: |
International journal of cardiology - 276(2019) vom: 01. Feb., Seite 130-135 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Potpara, Tatjana S [VerfasserIn] |
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| Links: |
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| Themen: |
AF recurrence post-ablation |
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| Anmerkungen: |
Date Completed 27.08.2019 Date Revised 10.12.2019 published: Print-Electronic CommentIn: Int J Cardiol. 2019 Feb 1;276:154-155. - PMID 30514578 Citation Status MEDLINE |
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| doi: |
10.1016/j.ijcard.2018.08.018 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM287652610 |
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| 100 | 1 | |a Potpara, Tatjana S |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Validation of the MB-LATER score for prediction of late recurrence after catheter-ablation of atrial fibrillation |
| 264 | 1 | |c 2019 | |
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| 500 | |a Date Completed 27.08.2019 | ||
| 500 | |a Date Revised 10.12.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Int J Cardiol. 2019 Feb 1;276:154-155. - PMID 30514578 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2018. Published by Elsevier B.V. | ||
| 520 | |a BACKGROUND: Reliable identification of atrial fibrillation (AF) patients more likely to be AF-free long-term post-single catheter ablation (CA) would facilitate appropriate risk communication to patients. We validated the recently proposed MB-LATER score for prediction of late recurrences of AF (LRAF) post-CA | ||
| 520 | |a METHODS: Patients who underwent CA for symptomatic AF refractory to ≥1 antiarrhythmic drugs at the Johns Hopkins Hospital, Baltimore, between March 2003 and December 2015, for whom ≥1-year post-CA follow-up data were available, were enrolled | ||
| 520 | |a RESULTS: Of 226 patients (median age 58.5 years [IQR: 52.0-65.0], 163 males [72.1%], 142 [62.8%] with paroxysmal AF), LRAF occurred in 133 patients (58.8%) during a median 2-year follow-up (IQR: 1.1-4.1). The mean MB-LATER score was significantly higher in patients with versus those without LRAF (2.4 ± 1.2 vs. 1.9 ± 1.3, p = 0.002) and showed modest but significant predictive ability for LRAF (AUC: 0.62 [95% CI: 0.54-0.69], p = 0.003). A score cut-off value of >2 showed the best predictive ability for LRAF (70.4% [61.5-77.9]), with modest sensitivity (42.9% [34.3-51.7]) and specificity (74.2% [64.1-82.7]). Kaplan-Meyer survival free from AF was significantly better for patients with a MB-LATER score of ≤2 than for those with a score of >2 (log-rank p = 0.005) | ||
| 520 | |a CONCLUSION: In our study, the MB-LATER score showed a significant but modest predictive ability for LRAF post-AF ablation. Further prospective validation is needed to better define the potential role of the MB-LATER score in patient selection and treatment decision-making post-AF ablation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Validation Study | |
| 650 | 4 | |a AF recurrence post-ablation | |
| 650 | 4 | |a Catheter-ablation of AF | |
| 650 | 4 | |a MB-LATER score | |
| 650 | 4 | |a Risk assessment | |
| 650 | 7 | |a Anti-Arrhythmia Agents |2 NLM | |
| 700 | 1 | |a Mujovic, Nebojsa |e verfasserin |4 aut | |
| 700 | 1 | |a Sivasambu, Bhradeev |e verfasserin |4 aut | |
| 700 | 1 | |a Shantsila, Alena |e verfasserin |4 aut | |
| 700 | 1 | |a Marinkovic, Milan |e verfasserin |4 aut | |
| 700 | 1 | |a Calkins, Hugh |e verfasserin |4 aut | |
| 700 | 1 | |a Spragg, David |e verfasserin |4 aut | |
| 700 | 1 | |a Lip, Gregory Y H |e verfasserin |4 aut | |
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