Preoperative administration of Omega-3 fatty acids on postoperative pain and acute-phase reactants in patients undergoing Roux-en-Y gastric bypass : A randomized clinical trial
Copyright © 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved..
BACKGROUND: The term "Immunonutrition" (IMN) describes the enteral administration of certain substrates with a theoretical immunomodulating function. From all the elements conforming these IMN formulas, Omega-3 fatty acids (O3FA) are hypothesized to be the most important component for immunomodulation, with increased anti-inflammatory and antioxidant effect.
PATIENTS AND METHODS: A prospective randomized clinical trial of all the patients undergoing laparoscopic Roux-en-Y gastric bypass was performed. Patients were randomly assigned into 2 groups: those patients receiving a preoperative balanced energy high-protein formula (Control Group) and those ones who received the same preoperative nutritional formula enriched with O3FA (Experimental Group). In both groups, there was a restriction to 900 Kcal/day. Nutritional intervention started 10 days before surgery and was maintained up to 8 h before the surgical act. Preoperative weight loss, postoperative pain, complications and acute phase reactants were investigated.
RESULTS: 40 patients were included in the study, 20 in each group. Preoperative excess weight loss (EWL) with the prescribed treatment was 10.6 ± 7.7% in Control Group and 14.1 ± 5.8% in the Experimental Group (p = 0.024). Mean postoperative pain was 25 ± 9.2 mm in Control group and 10,9 ± 4,4 mm in Experimental Group (p = 0.015). CRP determined 24 h after surgery was significantly lower in the Experimental Group than in the Control Group. There were not significant differences in complications, mortality or readmission rates between groups.
CONCLUSIONS: The use of a nutritional supplement enriched with O3FA is associated with a greater preoperative weight loss, reduced postoperative pain and decreased postoperative levels of C reactive protein.
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:38 |
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| Enthalten in: |
Clinical nutrition (Edinburgh, Scotland) - 38(2019), 4 vom: 15. Aug., Seite 1588-1593 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ruiz-Tovar, Jaime [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 22.06.2020 Date Revised 12.02.2021 published: Print-Electronic ClinicalTrials.gov: NCT03010280 CommentIn: Clin Nutr. 2020 Apr;39(4):1301. - PMID 32139109 Citation Status MEDLINE |
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| doi: |
10.1016/j.clnu.2018.07.026 |
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| PPN (Katalog-ID): |
NLM287364178 |
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| 100 | 1 | |a Ruiz-Tovar, Jaime |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Preoperative administration of Omega-3 fatty acids on postoperative pain and acute-phase reactants in patients undergoing Roux-en-Y gastric bypass |b A randomized clinical trial |
| 264 | 1 | |c 2019 | |
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| 500 | |a Date Completed 22.06.2020 | ||
| 500 | |a Date Revised 12.02.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ClinicalTrials.gov: NCT03010280 | ||
| 500 | |a CommentIn: Clin Nutr. 2020 Apr;39(4):1301. - PMID 32139109 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. | ||
| 520 | |a BACKGROUND: The term "Immunonutrition" (IMN) describes the enteral administration of certain substrates with a theoretical immunomodulating function. From all the elements conforming these IMN formulas, Omega-3 fatty acids (O3FA) are hypothesized to be the most important component for immunomodulation, with increased anti-inflammatory and antioxidant effect | ||
| 520 | |a PATIENTS AND METHODS: A prospective randomized clinical trial of all the patients undergoing laparoscopic Roux-en-Y gastric bypass was performed. Patients were randomly assigned into 2 groups: those patients receiving a preoperative balanced energy high-protein formula (Control Group) and those ones who received the same preoperative nutritional formula enriched with O3FA (Experimental Group). In both groups, there was a restriction to 900 Kcal/day. Nutritional intervention started 10 days before surgery and was maintained up to 8 h before the surgical act. Preoperative weight loss, postoperative pain, complications and acute phase reactants were investigated | ||
| 520 | |a RESULTS: 40 patients were included in the study, 20 in each group. Preoperative excess weight loss (EWL) with the prescribed treatment was 10.6 ± 7.7% in Control Group and 14.1 ± 5.8% in the Experimental Group (p = 0.024). Mean postoperative pain was 25 ± 9.2 mm in Control group and 10,9 ± 4,4 mm in Experimental Group (p = 0.015). CRP determined 24 h after surgery was significantly lower in the Experimental Group than in the Control Group. There were not significant differences in complications, mortality or readmission rates between groups | ||
| 520 | |a CONCLUSIONS: The use of a nutritional supplement enriched with O3FA is associated with a greater preoperative weight loss, reduced postoperative pain and decreased postoperative levels of C reactive protein | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a C reactive protein | |
| 650 | 4 | |a Immunonutrition | |
| 650 | 4 | |a Omega-3 fatty acids | |
| 650 | 4 | |a Postoperative pain | |
| 650 | 4 | |a Preoperative excess weight loss | |
| 650 | 4 | |a Sleeve gastrectomy | |
| 650 | 7 | |a Fatty Acids, Omega-3 |2 NLM | |
| 650 | 7 | |a C-Reactive Protein |2 NLM | |
| 650 | 7 | |a 9007-41-4 |2 NLM | |
| 700 | 1 | |a Blanca, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Garcia, Alejandro |e verfasserin |4 aut | |
| 700 | 1 | |a Gonzalez, Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Gutierrez, Sonsoles |e verfasserin |4 aut | |
| 700 | 1 | |a Paniagua, Amalia |e verfasserin |4 aut | |
| 700 | 1 | |a Prieto, Maria Jose |e verfasserin |4 aut | |
| 700 | 1 | |a Ramallo, Luisa |e verfasserin |4 aut | |
| 700 | 1 | |a Llanos, Lucia |e verfasserin |4 aut | |
| 700 | 1 | |a Duran, Manuel |e verfasserin |4 aut | |
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