Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors
Copyright © 2018, American Association for the Advancement of Science..
Messenger RNA encodes cellular function and phenotype. In the context of human cancer, it defines the identities of malignant cells and the diversity of tumor tissue. We studied 72,501 single-cell transcriptomes of human renal tumors and normal tissue from fetal, pediatric, and adult kidneys. We matched childhood Wilms tumor with specific fetal cell types, thus providing evidence for the hypothesis that Wilms tumor cells are aberrant fetal cells. In adult renal cell carcinoma, we identified a canonical cancer transcriptome that matched a little-known subtype of proximal convoluted tubular cell. Analyses of the tumor composition defined cancer-associated normal cells and delineated a complex vascular endothelial growth factor (VEGF) signaling circuit. Our findings reveal the precise cellular identities and compositions of human kidney tumors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:361 |
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| Enthalten in: |
Science (New York, N.Y.) - 361(2018), 6402 vom: 10. Aug., Seite 594-599 |
| Sprache: |
Englisch |
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Date Completed 05.09.2018 Date Revised 20.03.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.1126/science.aat1699 |
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NLM287327175 |
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| 245 | 1 | 0 | |a Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors |
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| 520 | |a Copyright © 2018, American Association for the Advancement of Science. | ||
| 520 | |a Messenger RNA encodes cellular function and phenotype. In the context of human cancer, it defines the identities of malignant cells and the diversity of tumor tissue. We studied 72,501 single-cell transcriptomes of human renal tumors and normal tissue from fetal, pediatric, and adult kidneys. We matched childhood Wilms tumor with specific fetal cell types, thus providing evidence for the hypothesis that Wilms tumor cells are aberrant fetal cells. In adult renal cell carcinoma, we identified a canonical cancer transcriptome that matched a little-known subtype of proximal convoluted tubular cell. Analyses of the tumor composition defined cancer-associated normal cells and delineated a complex vascular endothelial growth factor (VEGF) signaling circuit. Our findings reveal the precise cellular identities and compositions of human kidney tumors | ||
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| 700 | 1 | |a Botting, Rachel A |e verfasserin |4 aut | |
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