Large granular lymphocytic leukemia CD3-CD56- : a challenge for the biologist and the physician
Large granular lymphocyte leukemia (LGL) are chronic lymphoproliferative disorders classified into three main groups: T-cell LGL leukemia (T-LGL), aggressive NK-cell leukemia and chronic lymphoproliferative disorder of NK cells (NK-LGL). Patients with LGL leukemia exhibit chronic (>3 months) and moderate (<1G/L) to substantial monoclonal expansion of large granular lymphocytes in the peripheral blood. Cytologically, large granular lymphocytes are medium to large cells which are further characterized by an eccentric nucleus and a slightly basophilic cytoplasm containing azurophilic granules. Typically, T-LGL (CD3-and mostly CD8+) can be differentiated from NK-LGL disorders (CD3-) based on flow cytometry analysis. However, distinction between LGL leukemias can be tricky. We report here the case of a 47-year-old woman patient diagnosed with large granular lymphocytes leukemia associated with atypical CD3-CD56- immunophenotyping and clinical manifestations of pseudo-Felty's syndrome.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:76 |
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| Enthalten in: |
Annales de biologie clinique - 76(2018), 4 vom: 01. Aug., Seite 429-434 |
| Sprache: |
Französisch |
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| Weiterer Titel: |
Leucémie à grands lymphocytes granuleux CD3-CD56- : un défi pour le biologiste et le clinicien |
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| Beteiligte Personen: |
Cupaiolo, Roberto [VerfasserIn] |
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| Links: |
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| Themen: |
CD3 Complex |
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| Anmerkungen: |
Date Completed 05.11.2018 Date Revised 30.07.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1684/abc.2018.1367 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM287183017 |
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| 500 | |a Date Revised 30.07.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Large granular lymphocyte leukemia (LGL) are chronic lymphoproliferative disorders classified into three main groups: T-cell LGL leukemia (T-LGL), aggressive NK-cell leukemia and chronic lymphoproliferative disorder of NK cells (NK-LGL). Patients with LGL leukemia exhibit chronic (>3 months) and moderate (<1G/L) to substantial monoclonal expansion of large granular lymphocytes in the peripheral blood. Cytologically, large granular lymphocytes are medium to large cells which are further characterized by an eccentric nucleus and a slightly basophilic cytoplasm containing azurophilic granules. Typically, T-LGL (CD3-and mostly CD8+) can be differentiated from NK-LGL disorders (CD3-) based on flow cytometry analysis. However, distinction between LGL leukemias can be tricky. We report here the case of a 47-year-old woman patient diagnosed with large granular lymphocytes leukemia associated with atypical CD3-CD56- immunophenotyping and clinical manifestations of pseudo-Felty's syndrome | ||
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| 650 | 4 | |a pseudo-Felty's syndrome | |
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| 700 | 1 | |a Govaerts, Danielle |e verfasserin |4 aut | |
| 700 | 1 | |a Delefortrie, Quentin |e verfasserin |4 aut | |
| 700 | 1 | |a Corazza, Francis |e verfasserin |4 aut | |
| 700 | 1 | |a Chevalier, Charles |e verfasserin |4 aut | |
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