The efficacy of hesperidin for treatment of acute otitis media
Copyright © 2018 Elsevier B.V. All rights reserved..
OBJECTIVES: In this experimental study, the effect of hesperidin on the treatment of acute otitis media (AOM) was investigated in an AOM-induced rat model.
METHODS: In total, 35 rats were randomly divided into the following five groups (n=7): group 1 (control), group 2 (AOM with no treatment), group 3 (AOM+antibiotic), group 4 (AOM+hesperidin), and group 5 (AOM+hesperidin+antibiotic). On day 14, group 3,4 and 5 rats were given antibiotic and hesperidin via gavages, respectively. Histopathological and immunological analyses were performed and the results analyzed.
RESULTS: Serum levels of TNF-α, IL-4, IL-6 and IL-1β were significantly decreased in the hesperidin- and antibiotic-treated groups compared to the AOM group. The AOM+antibiotic and AOM+hesperidin groups demonstrated reduced histological damage compared to the AOM group. Between the AOM+antibiotic and AOM+hesperidin groups, significant differences in tympanic membrane thickness(ThicTM), inflammation(Inf), and sclerosis(Sc) values were observed. However, no difference in epithelial damage(DamEpith), was seen between the two groups. There was a significant difference in the AOM+antibiotic and AOM+antibiotic+hesperidin groups compared to AOM group (P<0.001).
CONCLUSIONS: In this study, we observed that both antibiotic and hesperidin treatment reduced AOM symptoms in an AOM-induced rat model. The values in AOM+antibiotic+hesperidin group were markedly lower than those of the other groups. From our results, we propose that hesperidin, in combination with antibiotics, may provide a successful alternative treatment for AOM compared with antibiotics used alone.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
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| Enthalten in: |
Auris, nasus, larynx - 46(2019), 2 vom: 15. Apr., Seite 172-177 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cetinkaya, Erdem Atalay [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 10.06.2019 Date Revised 13.06.2019 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.anl.2018.07.005 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM287117766 |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2018 Elsevier B.V. All rights reserved. | ||
| 520 | |a OBJECTIVES: In this experimental study, the effect of hesperidin on the treatment of acute otitis media (AOM) was investigated in an AOM-induced rat model | ||
| 520 | |a METHODS: In total, 35 rats were randomly divided into the following five groups (n=7): group 1 (control), group 2 (AOM with no treatment), group 3 (AOM+antibiotic), group 4 (AOM+hesperidin), and group 5 (AOM+hesperidin+antibiotic). On day 14, group 3,4 and 5 rats were given antibiotic and hesperidin via gavages, respectively. Histopathological and immunological analyses were performed and the results analyzed | ||
| 520 | |a RESULTS: Serum levels of TNF-α, IL-4, IL-6 and IL-1β were significantly decreased in the hesperidin- and antibiotic-treated groups compared to the AOM group. The AOM+antibiotic and AOM+hesperidin groups demonstrated reduced histological damage compared to the AOM group. Between the AOM+antibiotic and AOM+hesperidin groups, significant differences in tympanic membrane thickness(ThicTM), inflammation(Inf), and sclerosis(Sc) values were observed. However, no difference in epithelial damage(DamEpith), was seen between the two groups. There was a significant difference in the AOM+antibiotic and AOM+antibiotic+hesperidin groups compared to AOM group (P<0.001) | ||
| 520 | |a CONCLUSIONS: In this study, we observed that both antibiotic and hesperidin treatment reduced AOM symptoms in an AOM-induced rat model. The values in AOM+antibiotic+hesperidin group were markedly lower than those of the other groups. From our results, we propose that hesperidin, in combination with antibiotics, may provide a successful alternative treatment for AOM compared with antibiotics used alone | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acute otitis media | |
| 650 | 4 | |a Cytokines | |
| 650 | 4 | |a Hesperidin | |
| 650 | 4 | |a Histological examination | |
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