Familial hypercholesterolemia : An under-diagnosed and under-treated disease. Survey of 495 physicians
Copyright © 2018 Elsevier Masson SAS. All rights reserved..
INTRODUCTION: Heterozygous familial hypercholesterolemia (FH) is one of the most frequent genetic diseases with a prevalence of 1/250. It is characterized by a very high cholesterol level since birth and is often complicated by cardiovascular diseases (CV) in young patients. While early diagnosis and appropriate therapeutic management can avoid CV complications, HF is largely under-diagnosed and therefore under-treated.
METHODS: To investigate the management of HF in France, we conducted a survey with 495 general practitioners (n=200) and specialists (n=295).
RESULTS: The results revealed: a large underestimation of the CV risk and a high therapeutic inertia in the management of the affected patients. The practitioners reported a real need for more information about the disease.
CONCLUSION: Given the high frequency of HF and the associated cardiovascular morbidity and mortality, general practitioners have a decisive role to play for the identification and the management of these patients. The recent publication of HAS recommendations on family screening procedures and care of HF patients should improve the management of this disease.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:47 |
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| Enthalten in: |
Presse medicale (Paris, France : 1983) - 47(2018), 9 vom: 28. Sept., Seite e159-e167 |
| Sprache: |
Französisch |
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| Weiterer Titel: |
Hypercholestérolémie familiale peu diagnostiquée, insuffisamment traitée. Enquête auprès de 495 médecins |
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| Beteiligte Personen: |
Béliard, Sophie [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 09.11.2018 Date Revised 09.11.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.lpm.2018.01.025 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM287007707 |
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| 245 | 1 | 0 | |a Familial hypercholesterolemia |b An under-diagnosed and under-treated disease. Survey of 495 physicians |
| 246 | 3 | 3 | |a Hypercholestérolémie familiale peu diagnostiquée, insuffisamment traitée. Enquête auprès de 495 médecins |
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| 500 | |a Date Revised 09.11.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2018 Elsevier Masson SAS. All rights reserved. | ||
| 520 | |a INTRODUCTION: Heterozygous familial hypercholesterolemia (FH) is one of the most frequent genetic diseases with a prevalence of 1/250. It is characterized by a very high cholesterol level since birth and is often complicated by cardiovascular diseases (CV) in young patients. While early diagnosis and appropriate therapeutic management can avoid CV complications, HF is largely under-diagnosed and therefore under-treated | ||
| 520 | |a METHODS: To investigate the management of HF in France, we conducted a survey with 495 general practitioners (n=200) and specialists (n=295) | ||
| 520 | |a RESULTS: The results revealed: a large underestimation of the CV risk and a high therapeutic inertia in the management of the affected patients. The practitioners reported a real need for more information about the disease | ||
| 520 | |a CONCLUSION: Given the high frequency of HF and the associated cardiovascular morbidity and mortality, general practitioners have a decisive role to play for the identification and the management of these patients. The recent publication of HAS recommendations on family screening procedures and care of HF patients should improve the management of this disease | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Rabès, Jean-Pierre |e verfasserin |4 aut | |
| 700 | 1 | |a Cariou, Bertrand |e verfasserin |4 aut | |
| 700 | 1 | |a Farnier, Michel |e verfasserin |4 aut | |
| 700 | 1 | |a Krempf, Michel |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrières, Jean |e verfasserin |4 aut | |
| 700 | 1 | |a Danchin, Nicolas |e verfasserin |4 aut | |
| 700 | 1 | |a Bruckert, Eric |e verfasserin |4 aut | |
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