Toxicity of d-Arabinose in Male and Female Rats
In order to investigate the feasibility of using the rare sugar d-arabinose as a functional food material, we examined its toxicity in rats. In an acute toxicity study, the lethal dose (LD50) was calculated to be 12.1 g/kg in males and 11.6 g/kg in females. On the other hand, in a short-term toxicity test, rats developed diarrhea when given feed containing 5% d-arabinose, which was the minimum amount added, so the maximum nontoxic amount was estimated to be less than 5%. Thus, the toxicity of d-arabinose is stronger than that of another rare sugar, d-psicose, which was reported to show no toxicity when added at 10% in the diet. Further studies are needed to establish whether d-arabinose would be safe for use as a functional ingredient.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:59 |
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| Enthalten in: |
Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - 59(2018), 3 vom: 12., Seite 114-120 |
| Sprache: |
Japanisch |
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| Beteiligte Personen: |
Higaki, Shunsuke [VerfasserIn] |
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| Links: |
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| Themen: |
Arabinose |
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| Anmerkungen: |
Date Completed 21.06.2019 Date Revised 21.06.2019 published: Print Citation Status MEDLINE |
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| doi: |
10.3358/shokueishi.59.114 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM286743809 |
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| 520 | |a In order to investigate the feasibility of using the rare sugar d-arabinose as a functional food material, we examined its toxicity in rats. In an acute toxicity study, the lethal dose (LD50) was calculated to be 12.1 g/kg in males and 11.6 g/kg in females. On the other hand, in a short-term toxicity test, rats developed diarrhea when given feed containing 5% d-arabinose, which was the minimum amount added, so the maximum nontoxic amount was estimated to be less than 5%. Thus, the toxicity of d-arabinose is stronger than that of another rare sugar, d-psicose, which was reported to show no toxicity when added at 10% in the diet. Further studies are needed to establish whether d-arabinose would be safe for use as a functional ingredient | ||
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