Effect of antiretroviral therapy on allele-associated Lp(a) level in women with HIV in the Women's Interagency HIV Study
Copyright © 2018 Enkhmaa et al..
We previously demonstrated an association between lipoprotein (a) [Lp(a)] levels and atherosclerosis in human immunodeficiency virus (HIV)-seropositive women. The effects of antiretroviral therapy (ART) on Lp(a) levels in relation to apo(a) size polymorphism remain unclear. ART effects on allele-specific apo(a) level (ASL), an Lp(a) level associated with individual apo(a) alleles within each allele-pair, were determined in 126 HIV-seropositive women. ART effects were tested by a mixed-effects model across pre-ART and post-ART first and third visits. Data from 120 HIV-seronegative women were used. The mean age was 38 years; most were African-American (∼70%). Pre-ART ASLs associated with the larger (4.6 mg/dl vs. 8.0 mg/dl, P = 0.024) or smaller (13 mg/dl vs. 19 mg/dl, P = 0.041) apo(a) sizes were lower in the HIV-seropositive versus HIV-seronegative group, as was the prevalence of a high Lp(a) level (P = 0.013). Post-ART ASL and prevalence of high Lp(a) or apo(a) sizes and frequency of small size apo(a) (22 kringles) did not differ between the two groups. ART increased Lp(a) level (from 18 to 24 mg/dl, P < 0.0001) and both ASLs (P < 0.001). In conclusion, regardless of genetic control, Lp(a) can be modulated by HIV and its treatment. ART initiation abrogates HIV-induced suppression of Lp(a) levels and ASLs, contributing to promote CVD risk in HIV-seropositive individuals.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2018 |
|---|---|
| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:59 |
|---|---|
| Enthalten in: |
Journal of lipid research - 59(2018), 10 vom: 16. Okt., Seite 1967-1976 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Enkhmaa, Byambaa [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 22.08.2019 Date Revised 10.07.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1194/jlr.P084517 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM286535920 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM286535920 | ||
| 003 | DE-627 | ||
| 005 | 20231225051939.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1194/jlr.P084517 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0955.xml |
| 035 | |a (DE-627)NLM286535920 | ||
| 035 | |a (NLM)30012717 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Enkhmaa, Byambaa |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effect of antiretroviral therapy on allele-associated Lp(a) level in women with HIV in the Women's Interagency HIV Study |
| 264 | 1 | |c 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 22.08.2019 | ||
| 500 | |a Date Revised 10.07.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2018 Enkhmaa et al. | ||
| 520 | |a We previously demonstrated an association between lipoprotein (a) [Lp(a)] levels and atherosclerosis in human immunodeficiency virus (HIV)-seropositive women. The effects of antiretroviral therapy (ART) on Lp(a) levels in relation to apo(a) size polymorphism remain unclear. ART effects on allele-specific apo(a) level (ASL), an Lp(a) level associated with individual apo(a) alleles within each allele-pair, were determined in 126 HIV-seropositive women. ART effects were tested by a mixed-effects model across pre-ART and post-ART first and third visits. Data from 120 HIV-seronegative women were used. The mean age was 38 years; most were African-American (∼70%). Pre-ART ASLs associated with the larger (4.6 mg/dl vs. 8.0 mg/dl, P = 0.024) or smaller (13 mg/dl vs. 19 mg/dl, P = 0.041) apo(a) sizes were lower in the HIV-seropositive versus HIV-seronegative group, as was the prevalence of a high Lp(a) level (P = 0.013). Post-ART ASL and prevalence of high Lp(a) or apo(a) sizes and frequency of small size apo(a) (22 kringles) did not differ between the two groups. ART increased Lp(a) level (from 18 to 24 mg/dl, P < 0.0001) and both ASLs (P < 0.001). In conclusion, regardless of genetic control, Lp(a) can be modulated by HIV and its treatment. ART initiation abrogates HIV-induced suppression of Lp(a) levels and ASLs, contributing to promote CVD risk in HIV-seropositive individuals | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a apolipoprotein (a) sizes | |
| 650 | 4 | |a apolipoproteins | |
| 650 | 4 | |a biomarkers | |
| 650 | 4 | |a clinical studies | |
| 650 | 4 | |a drug therapy | |
| 650 | 4 | |a human immunodeficiency virus treatment | |
| 650 | 4 | |a lipoprotein (a) | |
| 650 | 4 | |a lipoproteins | |
| 650 | 4 | |a longitudinal design | |
| 650 | 4 | |a molecular biology/genetics | |
| 650 | 4 | |a prospective cohort | |
| 650 | 7 | |a Anti-HIV Agents |2 NLM | |
| 650 | 7 | |a Lipoprotein(a) |2 NLM | |
| 650 | 7 | |a Apoprotein(a) |2 NLM | |
| 650 | 7 | |a EC 3.4.21.- |2 NLM | |
| 700 | 1 | |a Anuurad, Erdembileg |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Chin-Shang |e verfasserin |4 aut | |
| 700 | 1 | |a Kaplan, Robert |e verfasserin |4 aut | |
| 700 | 1 | |a Lazar, Jason |e verfasserin |4 aut | |
| 700 | 1 | |a Merenstein, Dan |e verfasserin |4 aut | |
| 700 | 1 | |a Karim, Roksana |e verfasserin |4 aut | |
| 700 | 1 | |a Aouizerat, Brad |e verfasserin |4 aut | |
| 700 | 1 | |a Cohen, Mardge |e verfasserin |4 aut | |
| 700 | 1 | |a Butler, Kenneth |e verfasserin |4 aut | |
| 700 | 1 | |a Pahwa, Savita |e verfasserin |4 aut | |
| 700 | 1 | |a Ofotokun, Igho |e verfasserin |4 aut | |
| 700 | 1 | |a Adimora, Adaora A |e verfasserin |4 aut | |
| 700 | 1 | |a Golub, Elizabeth |e verfasserin |4 aut | |
| 700 | 1 | |a Berglund, Lars |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of lipid research |d 1960 |g 59(2018), 10 vom: 16. Okt., Seite 1967-1976 |w (DE-627)NLM000005878 |x 1539-7262 |7 nnns |
| 773 | 1 | 8 | |g volume:59 |g year:2018 |g number:10 |g day:16 |g month:10 |g pages:1967-1976 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1194/jlr.P084517 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 59 |j 2018 |e 10 |b 16 |c 10 |h 1967-1976 | ||