Acquired aplastic anemia. Experience in a public hospital
BACKGROUND: The first line treatment for patients < 40 years old with aplastic anemia (AA) is allogeneic HLA-identical sibling donor transplantation (SCT). Immunosuppressive therapy (IST) with a combination of Thymoglobuline (ATG) and cyclosporine is used for older patients or those without a donor. Five year overall survival (OS) for both therapies is > 70%.
AIM: To report the experience with SCT and ATG for AA in a public hospital.
PATIENTS AND METHODS: AA was diagnosed in 42 patients between 1998 and 2016, according to Camitta criteria. Thirty eight (90%) received treatment, 7 (18%) under 40 years old received SCT, and 31 (82%) IST. The rest were not treated. OS was calculated from date of diagnosis until last control, death or loss from follow up.
RESULTS: Complete or partial hematologic response, was obtained in 71% and 58% of cases with SCT and IS, respectively. Five year OS was 71% and 55% with SCT and IST, respectively. No difference in response was observed between horse and rabbit ATG.
CONCLUSIONS: SCT from an HLA-identical sibling donor had a high response rate and survival. IST instead, had a lower response and survival, due to an initial high mortality rate.
| Errataetall: |
CommentIn: Rev Med Chil. 2018 Sep;146(9):1085. - PMID 30725033 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:146 |
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| Enthalten in: |
Revista medica de Chile - 146(2018), 2 vom: 07. Feb., Seite 175-182 |
| Sprache: |
Spanisch |
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| Weiterer Titel: |
Aplasia medular adquirida, experiencia en un hospital público de referencia |
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| Beteiligte Personen: |
León, Pilar [VerfasserIn] |
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| Links: |
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| Themen: |
83HN0GTJ6D |
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| Anmerkungen: |
Date Completed 26.07.2018 Date Revised 26.07.2018 published: Print CommentIn: Rev Med Chil. 2018 Sep;146(9):1085. - PMID 30725033 Citation Status MEDLINE |
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| doi: |
10.4067/s0034-98872018000200175 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a CommentIn: Rev Med Chil. 2018 Sep;146(9):1085. - PMID 30725033 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: The first line treatment for patients < 40 years old with aplastic anemia (AA) is allogeneic HLA-identical sibling donor transplantation (SCT). Immunosuppressive therapy (IST) with a combination of Thymoglobuline (ATG) and cyclosporine is used for older patients or those without a donor. Five year overall survival (OS) for both therapies is > 70% | ||
| 520 | |a AIM: To report the experience with SCT and ATG for AA in a public hospital | ||
| 520 | |a PATIENTS AND METHODS: AA was diagnosed in 42 patients between 1998 and 2016, according to Camitta criteria. Thirty eight (90%) received treatment, 7 (18%) under 40 years old received SCT, and 31 (82%) IST. The rest were not treated. OS was calculated from date of diagnosis until last control, death or loss from follow up | ||
| 520 | |a RESULTS: Complete or partial hematologic response, was obtained in 71% and 58% of cases with SCT and IS, respectively. Five year OS was 71% and 55% with SCT and IST, respectively. No difference in response was observed between horse and rabbit ATG | ||
| 520 | |a CONCLUSIONS: SCT from an HLA-identical sibling donor had a high response rate and survival. IST instead, had a lower response and survival, due to an initial high mortality rate | ||
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