Premorbid academic and social functioning in patients with schizophrenia and its associations with negative symptoms and cognition
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd..
OBJECTIVE: The study aimed to explore premorbid academic and social functioning in patients with schizophrenia, and its associations with the severity of negative symptoms and neurocognitive impairment.
METHOD: Premorbid adjustment (PA) in patients with schizophrenia was compared to early adjustment in unaffected first-degree relatives and healthy controls. Its associations with psychopathology, cognition, and real-life functioning were investigated. The associations of PA with primary negative symptoms and their two factors were explored.
RESULTS: We found an impairment of academic and social PA in patients (P ≤ 0.000001) and an impairment of academic aspects of early adjustment in relatives (P ≤ 0.01). Patients with poor PA showed greater severity of negative symptoms (limited to avolition after excluding the effect of depression/parkinsonism), working memory, social cognition, and real-life functioning (P ≤ 0.01 to ≤0.000001). Worse academic and social PA were associated with greater severity of psychopathology, cognitive impairment, and real-life functioning impairment (P ≤ 0.000001). Regression analyses showed that worse PA in the academic domain was mainly associated to the impairment of working memory, whereas worse PA in the social domain to avolition (P ≤ 0.000001).
CONCLUSION: Our findings suggest that poor early adjustment may represent a marker of vulnerability to schizophrenia and highlight the need for preventive/early interventions based on psychosocial and/or cognitive programs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:138 |
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| Enthalten in: |
Acta psychiatrica Scandinavica - 138(2018), 3 vom: 30. Sept., Seite 253-266 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bucci, P [VerfasserIn] |
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| Links: |
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| Themen: |
Avolition |
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| Anmerkungen: |
Date Completed 14.10.2019 Date Revised 14.10.2019 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/acps.12938 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM286271168 |
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| 100 | 1 | |a Bucci, P |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Premorbid academic and social functioning in patients with schizophrenia and its associations with negative symptoms and cognition |
| 264 | 1 | |c 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 14.10.2019 | ||
| 500 | |a Date Revised 14.10.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. | ||
| 520 | |a OBJECTIVE: The study aimed to explore premorbid academic and social functioning in patients with schizophrenia, and its associations with the severity of negative symptoms and neurocognitive impairment | ||
| 520 | |a METHOD: Premorbid adjustment (PA) in patients with schizophrenia was compared to early adjustment in unaffected first-degree relatives and healthy controls. Its associations with psychopathology, cognition, and real-life functioning were investigated. The associations of PA with primary negative symptoms and their two factors were explored | ||
| 520 | |a RESULTS: We found an impairment of academic and social PA in patients (P ≤ 0.000001) and an impairment of academic aspects of early adjustment in relatives (P ≤ 0.01). Patients with poor PA showed greater severity of negative symptoms (limited to avolition after excluding the effect of depression/parkinsonism), working memory, social cognition, and real-life functioning (P ≤ 0.01 to ≤0.000001). Worse academic and social PA were associated with greater severity of psychopathology, cognitive impairment, and real-life functioning impairment (P ≤ 0.000001). Regression analyses showed that worse PA in the academic domain was mainly associated to the impairment of working memory, whereas worse PA in the social domain to avolition (P ≤ 0.000001) | ||
| 520 | |a CONCLUSION: Our findings suggest that poor early adjustment may represent a marker of vulnerability to schizophrenia and highlight the need for preventive/early interventions based on psychosocial and/or cognitive programs | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a avolition | |
| 650 | 4 | |a cognitive functioning | |
| 650 | 4 | |a poor emotion expression | |
| 650 | 4 | |a premorbid adjustment | |
| 650 | 4 | |a primary negative symptoms | |
| 700 | 1 | |a Galderisi, S |e verfasserin |4 aut | |
| 700 | 1 | |a Mucci, A |e verfasserin |4 aut | |
| 700 | 1 | |a Rossi, A |e verfasserin |4 aut | |
| 700 | 1 | |a Rocca, P |e verfasserin |4 aut | |
| 700 | 1 | |a Bertolino, A |e verfasserin |4 aut | |
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| 700 | 1 | |a Aiello, Carmen |e investigator |4 oth | |
| 700 | 1 | |a Longo, Luisa |e investigator |4 oth | |
| 700 | 1 | |a Barone, Marina |e investigator |4 oth | |
| 700 | 1 | |a Romano, Raffaella |e investigator |4 oth | |
| 700 | 1 | |a Atti, Anna Rita |e investigator |4 oth | |
| 700 | 1 | |a Barlati, Stefano |e investigator |4 oth | |
| 700 | 1 | |a Deste, Giacomo |e investigator |4 oth | |
| 700 | 1 | |a Valsecchi, Paolo |e investigator |4 oth | |
| 700 | 1 | |a Carpiniello, Bernardo |e investigator |4 oth | |
| 700 | 1 | |a Tusconi, Massimo |e investigator |4 oth | |
| 700 | 1 | |a Puddu, Laura |e investigator |4 oth | |
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