Leptin and ghrelin in chronic kidney disease : their associations with protein-energy wasting
BACKGROUND: This study aimed to evaluate plasma concentrations of leptin and total ghrelin in children with chronic kidney disease (CKD) and assess their roles in protein-energy wasting (PEW).
METHODS: This study consisted of three different CKD populations [CKD group (20 patients with non-dialysis CKD), dialysis group (39 patients on dialysis), and kidney transplant (KTx) group (35 KTx recipients)] and control group (18 healthy children). Plasma leptin and total ghrelin levels were measured. Multi-frequency bioimpedance analysis was used for the assessment of fat and lean mass. PEW was defined using criteria including body mass, muscle mass, growth, serum albumin level, and protein intake.
RESULTS: While plasma leptin levels did not differ among the study groups, total ghrelin levels were significantly higher in the dialysis group (P < 0.001). Seven dialysis patients (18%) and one CKD patient (5%) but none of the KTx recipients met the criteria of PEW. Dialysis patients with PEW had lower plasma leptin levels compared to their counterparts (P = 0.018); however, total ghrelin levels did not differ between the two groups (P = 0.10). Low leptin level in dialysis patients was independently associated with lower fat mass index (P < 0.001) and lower height-specific SD scores of BMI (P = 0.019).
CONCLUSIONS: PEW is prevalent in dialysis patients. Low levels of leptin seem to be associated with PEW. Our result suggests that low leptin levels may be a consequence rather than a cause of PEW. Longitudinal studies are required to investigate this complex relationship between leptin and PEW in pediatric dialysis patients.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2018 |
|---|---|
| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:33 |
|---|---|
| Enthalten in: |
Pediatric nephrology (Berlin, Germany) - 33(2018), 11 vom: 06. Nov., Seite 2113-2122 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Canpolat, Nur [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Children |
|---|
| Anmerkungen: |
Date Completed 27.09.2019 Date Revised 27.09.2019 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1007/s00467-018-4002-7 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM286235870 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM286235870 | ||
| 003 | DE-627 | ||
| 005 | 20231225051228.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00467-018-4002-7 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0954.xml |
| 035 | |a (DE-627)NLM286235870 | ||
| 035 | |a (NLM)29980850 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Canpolat, Nur |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Leptin and ghrelin in chronic kidney disease |b their associations with protein-energy wasting |
| 264 | 1 | |c 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 27.09.2019 | ||
| 500 | |a Date Revised 27.09.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: This study aimed to evaluate plasma concentrations of leptin and total ghrelin in children with chronic kidney disease (CKD) and assess their roles in protein-energy wasting (PEW) | ||
| 520 | |a METHODS: This study consisted of three different CKD populations [CKD group (20 patients with non-dialysis CKD), dialysis group (39 patients on dialysis), and kidney transplant (KTx) group (35 KTx recipients)] and control group (18 healthy children). Plasma leptin and total ghrelin levels were measured. Multi-frequency bioimpedance analysis was used for the assessment of fat and lean mass. PEW was defined using criteria including body mass, muscle mass, growth, serum albumin level, and protein intake | ||
| 520 | |a RESULTS: While plasma leptin levels did not differ among the study groups, total ghrelin levels were significantly higher in the dialysis group (P < 0.001). Seven dialysis patients (18%) and one CKD patient (5%) but none of the KTx recipients met the criteria of PEW. Dialysis patients with PEW had lower plasma leptin levels compared to their counterparts (P = 0.018); however, total ghrelin levels did not differ between the two groups (P = 0.10). Low leptin level in dialysis patients was independently associated with lower fat mass index (P < 0.001) and lower height-specific SD scores of BMI (P = 0.019) | ||
| 520 | |a CONCLUSIONS: PEW is prevalent in dialysis patients. Low levels of leptin seem to be associated with PEW. Our result suggests that low leptin levels may be a consequence rather than a cause of PEW. Longitudinal studies are required to investigate this complex relationship between leptin and PEW in pediatric dialysis patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Children | |
| 650 | 4 | |a Chronic kidney disease | |
| 650 | 4 | |a Dialysis | |
| 650 | 4 | |a Ghrelin | |
| 650 | 4 | |a Leptin | |
| 650 | 4 | |a PEW | |
| 650 | 4 | |a Protein-energy wasting | |
| 650 | 7 | |a GHRL protein, human |2 NLM | |
| 650 | 7 | |a Ghrelin |2 NLM | |
| 650 | 7 | |a LEP protein, human |2 NLM | |
| 650 | 7 | |a Leptin |2 NLM | |
| 700 | 1 | |a Sever, Lale |e verfasserin |4 aut | |
| 700 | 1 | |a Agbas, Ayse |e verfasserin |4 aut | |
| 700 | 1 | |a Tasdemir, Mehmet |e verfasserin |4 aut | |
| 700 | 1 | |a Oruc, Cigdem |e verfasserin |4 aut | |
| 700 | 1 | |a Ekmekci, Ozlem Balcı |e verfasserin |4 aut | |
| 700 | 1 | |a Caliskan, Salim |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pediatric nephrology (Berlin, Germany) |d 1995 |g 33(2018), 11 vom: 06. Nov., Seite 2113-2122 |w (DE-627)NLM012612111 |x 1432-198X |7 nnns |
| 773 | 1 | 8 | |g volume:33 |g year:2018 |g number:11 |g day:06 |g month:11 |g pages:2113-2122 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00467-018-4002-7 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 33 |j 2018 |e 11 |b 06 |c 11 |h 2113-2122 | ||