Tamarind seed coat extract restores fluoride-induced hematological and biochemical alterations in rats
Fluoride (F-) is becoming an ineluctable environmental pollutant causing deleterious effects in humans. In the present study, we examined whether tamarind seed coat extract (TSCE) is beneficial against the F--induced systemic toxicity and hematological changes. Wistar rats were randomly grouped as follows: group I served as control; group II intoxicated with sodium fluoride (NaF, 300 ppm) in drinking water; group III was administered through oral intubation with TSCE (100 mg/kg bw); group IV was treated with NaF (300 ppm) in association with TSCE (100 mg/kg bw) for 30 days. The results indicated that F- exposure induced oxidative stress as evidenced by elevated levels of reactive oxygen species and lipid peroxidation in the brain, liver, and kidney. F- administration modulates hematological indices-WBC, RBC, and mean corpuscular volume. Moreover, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, acetylcholinesterase, and monoamine oxidase significantly increased on F- exposure. Conversely, δ-aminolevulinic acid dehydratase and glutathione/reduced glutathione ratio were decreased. Activity of antioxidants-superoxide dismutase, catalase, glutathione peroxidase, and vitamin C-was also significantly decreased due to F- administration. Treatment with TSCE effectively mitigated the alterations through its antioxidant potential. The data suggested that the TSCE had beneficial effects in alleviating the F--induced toxicity and hence can serve as a promising neutraceutical agent.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Environmental science and pollution research international - 25(2018), 26 vom: 03. Sept., Seite 26157-26166 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ameeramja, Jaishabanu [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 02.01.2019 Date Revised 02.01.2019 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s11356-018-2667-x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM28614686X |
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| 500 | |a Date Revised 02.01.2019 | ||
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Fluoride (F-) is becoming an ineluctable environmental pollutant causing deleterious effects in humans. In the present study, we examined whether tamarind seed coat extract (TSCE) is beneficial against the F--induced systemic toxicity and hematological changes. Wistar rats were randomly grouped as follows: group I served as control; group II intoxicated with sodium fluoride (NaF, 300 ppm) in drinking water; group III was administered through oral intubation with TSCE (100 mg/kg bw); group IV was treated with NaF (300 ppm) in association with TSCE (100 mg/kg bw) for 30 days. The results indicated that F- exposure induced oxidative stress as evidenced by elevated levels of reactive oxygen species and lipid peroxidation in the brain, liver, and kidney. F- administration modulates hematological indices-WBC, RBC, and mean corpuscular volume. Moreover, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, acetylcholinesterase, and monoamine oxidase significantly increased on F- exposure. Conversely, δ-aminolevulinic acid dehydratase and glutathione/reduced glutathione ratio were decreased. Activity of antioxidants-superoxide dismutase, catalase, glutathione peroxidase, and vitamin C-was also significantly decreased due to F- administration. Treatment with TSCE effectively mitigated the alterations through its antioxidant potential. The data suggested that the TSCE had beneficial effects in alleviating the F--induced toxicity and hence can serve as a promising neutraceutical agent | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Biochemical toxicity | |
| 650 | 4 | |a Hematology | |
| 650 | 4 | |a Oxidative stress | |
| 650 | 4 | |a Rats | |
| 650 | 4 | |a Sodium fluoride | |
| 650 | 4 | |a Tamarind seed coat extract | |
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| 700 | 1 | |a Perumal, Ekambaram |e verfasserin |4 aut | |
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