Therapeutic effect of dental pulp stem cell transplantation on a rat model of radioactivity-induced esophageal injury
Dental pulp stem cell (DPSC) transplantation has been demonstrated to promote the regeneration and repair of tissues and organs and is a potentially effective treatment for radioactive esophageal injury. In this study, to explore the therapeutic effects of DPSCs on acute radiation-induced esophageal injury, DPSCs were cultured and transplanted into rats with acute radioactive esophageal injuries induced by radioactive 125I seeds in vivo. In the injured esophagus, PKH26-labeled DPSCs co-localized with PCNA, CK14, CD71, and integrin α6, and the expression levels of these four makers of esophageal stem cells were significantly increased. After DPSC transplantation, the injured esophagus exhibited a greater thickness. In addition, the esophageal function and inflammation recovered faster. The results demonstrated that transplanted DPSCs, which trans-differentiated into esophageal stem cells in vivo, could repair the damaged esophageal tissue.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Cell death & disease - 9(2018), 7 vom: 03. Juli, Seite 738 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Chunwei [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 25.11.2019 Date Revised 25.11.2019 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41419-018-0753-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM28613845X |
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| 245 | 1 | 0 | |a Therapeutic effect of dental pulp stem cell transplantation on a rat model of radioactivity-induced esophageal injury |
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| 520 | |a Dental pulp stem cell (DPSC) transplantation has been demonstrated to promote the regeneration and repair of tissues and organs and is a potentially effective treatment for radioactive esophageal injury. In this study, to explore the therapeutic effects of DPSCs on acute radiation-induced esophageal injury, DPSCs were cultured and transplanted into rats with acute radioactive esophageal injuries induced by radioactive 125I seeds in vivo. In the injured esophagus, PKH26-labeled DPSCs co-localized with PCNA, CK14, CD71, and integrin α6, and the expression levels of these four makers of esophageal stem cells were significantly increased. After DPSC transplantation, the injured esophagus exhibited a greater thickness. In addition, the esophageal function and inflammation recovered faster. The results demonstrated that transplanted DPSCs, which trans-differentiated into esophageal stem cells in vivo, could repair the damaged esophageal tissue | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Zhang, Yichi |e verfasserin |4 aut | |
| 700 | 1 | |a Feng, Zhenning |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Feifei |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Zishuai |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Xiaoli |e verfasserin |4 aut | |
| 700 | 1 | |a Ruan, Mengting |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Mingna |e verfasserin |4 aut | |
| 700 | 1 | |a Jin, Shizhu |e verfasserin |4 aut | |
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