Impact of primary tumor side on the outcomes of patients with non-metastatic colon cancer; a patient-level pooled analysis of two clinical trials
OBJECTIVE: To assess the impact of primary tumor side on the outcomes of non-metastatic colon cancer patients included in two clinical trials.
METHODS: Overall and disease-free survivals were assessed according to the side of the tumor, through Kaplan-Meier analysis. Univariate and Multivariate analysis of predictors of disease-free survival was performed through Cox regression analysis.
RESULTS: Kaplan-Meier analysis of disease-free survival according to the side of the primary tumor was conducted. In the overall cohort, the right-sided disease has longer disease-free survival compared to left-sided disease (p = 0.005). When the analysis was repeated among different treatment strata (observation, adjuvant 5FU/LCV, adjuvant edrecolomab), right-sided colon cancer has longer disease-free survival among observation-treated patients only (p = 0.020). Multivariate analysis was conducted among the three subsets of adjuvant treatment. The left side of the primary tumor was predictive of worse disease-free survival in patients treated with observation only (p = 0.005) but not in patients treated with adjuvant 5FU/LCV (p = 0.345) or patients treated with adjuvant edrecolomab (p = 0.661).
CONCLUSION: Stage II right-sided colon cancer patients have better disease-free survival compared to stage II left-sided colon cancer patients when treated with surgery only. This survival difference disappears if patients were treated with adjuvant fluoropyrimidines.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2018 |
|---|---|
| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
|---|---|
| Enthalten in: |
Expert review of gastroenterology & hepatology - 12(2018), 8 vom: 01. Aug., Seite 843-848 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Giryes, Anwar [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Adjuvant treatment |
|---|
| Anmerkungen: |
Date Completed 23.10.2018 Date Revised 23.10.2018 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1080/17474124.2018.1495075 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM286095041 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM286095041 | ||
| 003 | DE-627 | ||
| 005 | 20231225050906.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/17474124.2018.1495075 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0953.xml |
| 035 | |a (DE-627)NLM286095041 | ||
| 035 | |a (NLM)29966444 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Giryes, Anwar |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Impact of primary tumor side on the outcomes of patients with non-metastatic colon cancer; a patient-level pooled analysis of two clinical trials |
| 264 | 1 | |c 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 23.10.2018 | ||
| 500 | |a Date Revised 23.10.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To assess the impact of primary tumor side on the outcomes of non-metastatic colon cancer patients included in two clinical trials | ||
| 520 | |a METHODS: Overall and disease-free survivals were assessed according to the side of the tumor, through Kaplan-Meier analysis. Univariate and Multivariate analysis of predictors of disease-free survival was performed through Cox regression analysis | ||
| 520 | |a RESULTS: Kaplan-Meier analysis of disease-free survival according to the side of the primary tumor was conducted. In the overall cohort, the right-sided disease has longer disease-free survival compared to left-sided disease (p = 0.005). When the analysis was repeated among different treatment strata (observation, adjuvant 5FU/LCV, adjuvant edrecolomab), right-sided colon cancer has longer disease-free survival among observation-treated patients only (p = 0.020). Multivariate analysis was conducted among the three subsets of adjuvant treatment. The left side of the primary tumor was predictive of worse disease-free survival in patients treated with observation only (p = 0.005) but not in patients treated with adjuvant 5FU/LCV (p = 0.345) or patients treated with adjuvant edrecolomab (p = 0.661) | ||
| 520 | |a CONCLUSION: Stage II right-sided colon cancer patients have better disease-free survival compared to stage II left-sided colon cancer patients when treated with surgery only. This survival difference disappears if patients were treated with adjuvant fluoropyrimidines | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Tumor side | |
| 650 | 4 | |a adjuvant treatment | |
| 650 | 4 | |a colon cancer | |
| 650 | 4 | |a survival | |
| 700 | 1 | |a Oweira, Hani |e verfasserin |4 aut | |
| 700 | 1 | |a Mannhart, Meinrad |e verfasserin |4 aut | |
| 700 | 1 | |a Abdel-Rahman, Omar |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Expert review of gastroenterology & hepatology |d 2007 |g 12(2018), 8 vom: 01. Aug., Seite 843-848 |w (DE-627)NLM185080200 |x 1747-4132 |7 nnns |
| 773 | 1 | 8 | |g volume:12 |g year:2018 |g number:8 |g day:01 |g month:08 |g pages:843-848 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/17474124.2018.1495075 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 12 |j 2018 |e 8 |b 01 |c 08 |h 843-848 | ||