Nanoemulsion-Loaded Hydrogels for Topical Administration of Pentyl Gallate
The aim of this study is to describe the development of nanoemulsion-loaded hydrogels to deliver pentyl gallate (PG), a gallic acid n-alkyl ester, through the skin. PG is an antioxidant agent; however, it seems to be a promising agent for herpis labialis treatment. Aristoflex AVC® and chitosan were used as gelling agents for nanoemulsion thickening. The developed formulations presented suitable PG content (94.4-100.3% w/w), nanometric droplet sizes (162-297 nm), high zeta potentials, and a non-Newtonian pseudoplastic behavior. Both vehicles neither enhanced PG penetration nor delayed its release from the nanoemulsion. Formulations remained physically stable at 8°C during 3 months of storage.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2018 |
|---|---|
| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
|---|---|
| Enthalten in: |
AAPS PharmSciTech - 19(2018), 6 vom: 26. Aug., Seite 2672-2678 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Kelmann, Regina G [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
632XD903SP |
|---|
| Anmerkungen: |
Date Completed 18.10.2018 Date Revised 18.10.2018 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1208/s12249-018-1099-8 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM28586646X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM28586646X | ||
| 003 | DE-627 | ||
| 005 | 20231225050403.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1208/s12249-018-1099-8 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0952.xml |
| 035 | |a (DE-627)NLM28586646X | ||
| 035 | |a (NLM)29943283 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Kelmann, Regina G |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Nanoemulsion-Loaded Hydrogels for Topical Administration of Pentyl Gallate |
| 264 | 1 | |c 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 18.10.2018 | ||
| 500 | |a Date Revised 18.10.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The aim of this study is to describe the development of nanoemulsion-loaded hydrogels to deliver pentyl gallate (PG), a gallic acid n-alkyl ester, through the skin. PG is an antioxidant agent; however, it seems to be a promising agent for herpis labialis treatment. Aristoflex AVC® and chitosan were used as gelling agents for nanoemulsion thickening. The developed formulations presented suitable PG content (94.4-100.3% w/w), nanometric droplet sizes (162-297 nm), high zeta potentials, and a non-Newtonian pseudoplastic behavior. Both vehicles neither enhanced PG penetration nor delayed its release from the nanoemulsion. Formulations remained physically stable at 8°C during 3 months of storage | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a hydrogel | |
| 650 | 4 | |a nanoemulsion | |
| 650 | 4 | |a pentyl gallate | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a Emulsions |2 NLM | |
| 650 | 7 | |a Hydrogels |2 NLM | |
| 650 | 7 | |a pentyl gallate |2 NLM | |
| 650 | 7 | |a Gallic Acid |2 NLM | |
| 650 | 7 | |a 632XD903SP |2 NLM | |
| 700 | 1 | |a Colombo, Mariana |e verfasserin |4 aut | |
| 700 | 1 | |a Nunes, Ricardo J |e verfasserin |4 aut | |
| 700 | 1 | |a Simões, Cláudia M O |e verfasserin |4 aut | |
| 700 | 1 | |a Koester, Letícia S |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t AAPS PharmSciTech |d 2000 |g 19(2018), 6 vom: 26. Aug., Seite 2672-2678 |w (DE-627)NLM126699429 |x 1530-9932 |7 nnns |
| 773 | 1 | 8 | |g volume:19 |g year:2018 |g number:6 |g day:26 |g month:08 |g pages:2672-2678 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1208/s12249-018-1099-8 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 19 |j 2018 |e 6 |b 26 |c 08 |h 2672-2678 | ||