Pharmacokinetic evaluation of D-ribose after oral and intravenous administration to healthy rabbits
INTRODUCTION: This study explored D-ribose pharmacokinetics after intravenous (IV) and oral administration to healthy rabbits.
MATERIALS AND METHODS: D-ribose was administered once as 420 mg/kg (N=4) or 840 mg/kg (N=6) dose intravenously, or as an oral dose of 420 mg/kg (N=3) or 840 mg/kg (N=3). Serum was obtained at various time points, up to 210 minutes after administration. Urine was also collected after IV administration. Pharmacokinetic parameters were determined from drug concentration-time data using Kinetica software.
RESULTS: The findings showed that D-ribose follows a dose-dependent kinetic profile. With doubling the IV dose, AUCtotal was significantly increased by threefold, while the clearance was decreased by 44%. The half-life was 1.7-fold longer at the higher dose. Similar nonsignificant trends were also observed at oral administration. D-ribose was rapidly absorbed (Tmax=36-44 minutes) and rapidly disappeared from plasma (within <140 minutes). Additionally, D-ribose was partially (18-37.5%) recovered from urine.
CONCLUSION: Collectively, D-ribose showed a dose-dependent kinetic profile, where parameters change according to dosing levels. D-ribose clearance seems to follow first-order kinetics at low dose. Thereafter, elimination systems are saturated, and elimination continues in a fast manner. Urine recovery was partial, which could be attributed to the several metabolic pathways that pentose can undergo.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Clinical pharmacology : advances and applications - 10(2018) vom: 20., Seite 73-78 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Alzoubi, Karem H [VerfasserIn] |
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| Links: |
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| Themen: |
D-ribose |
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| Anmerkungen: |
Date Revised 27.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.2147/CPAA.S167150 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM285718940 |
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| 245 | 1 | 0 | |a Pharmacokinetic evaluation of D-ribose after oral and intravenous administration to healthy rabbits |
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| 500 | |a Date Revised 27.03.2024 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a INTRODUCTION: This study explored D-ribose pharmacokinetics after intravenous (IV) and oral administration to healthy rabbits | ||
| 520 | |a MATERIALS AND METHODS: D-ribose was administered once as 420 mg/kg (N=4) or 840 mg/kg (N=6) dose intravenously, or as an oral dose of 420 mg/kg (N=3) or 840 mg/kg (N=3). Serum was obtained at various time points, up to 210 minutes after administration. Urine was also collected after IV administration. Pharmacokinetic parameters were determined from drug concentration-time data using Kinetica software | ||
| 520 | |a RESULTS: The findings showed that D-ribose follows a dose-dependent kinetic profile. With doubling the IV dose, AUCtotal was significantly increased by threefold, while the clearance was decreased by 44%. The half-life was 1.7-fold longer at the higher dose. Similar nonsignificant trends were also observed at oral administration. D-ribose was rapidly absorbed (Tmax=36-44 minutes) and rapidly disappeared from plasma (within <140 minutes). Additionally, D-ribose was partially (18-37.5%) recovered from urine | ||
| 520 | |a CONCLUSION: Collectively, D-ribose showed a dose-dependent kinetic profile, where parameters change according to dosing levels. D-ribose clearance seems to follow first-order kinetics at low dose. Thereafter, elimination systems are saturated, and elimination continues in a fast manner. Urine recovery was partial, which could be attributed to the several metabolic pathways that pentose can undergo | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a D-ribose | |
| 650 | 4 | |a intravenous | |
| 650 | 4 | |a oral | |
| 650 | 4 | |a pharmacokinetics | |
| 650 | 4 | |a rabbits | |
| 650 | 4 | |a single dose | |
| 700 | 1 | |a Ismail, Zuhair Bani |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Essa, Mohamed K |e verfasserin |4 aut | |
| 700 | 1 | |a Alshogran, Osama Y |e verfasserin |4 aut | |
| 700 | 1 | |a Abutayeh, Reem F |e verfasserin |4 aut | |
| 700 | 1 | |a Abu-Baker, Nareman |e verfasserin |4 aut | |
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