The Spectrum of Biopsy-Proven Glomerular Diseases among Children in China : A National, Cross-Sectional Survey
Copyright © 2018 by the American Society of Nephrology..
BACKGROUND AND OBJECTIVES: High-quality epidemiologic data on the spectrum of biopsy-proven glomerular diseases among children are limited. This study aimed to determine the profile of and temporal change in biopsy-proven pediatric glomerular diseases in China.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We previously conducted a nationwide kidney biopsy survey including 71,151 patients over an 11-year period from January 2004 to December 2014. A total of 7962 children younger than 18 years old from 115 hospitals across China with biopsy-proven glomerular diseases were included in this study. The demographic and clinical variables were extracted from referral records and pathology reports. The composition of pediatric glomerular diseases and clinicopathologic correlations in different sexes, age groups, and regions were assessed. The changing patterns of common glomerulopathies over the study period were examined.
RESULTS: Nephrotic syndrome (50%) was the most frequent indication for kidney biopsy in children. Minimal change disease was the most common primary glomerular disease (29%) followed by IgA nephropathy (17%). Henoch-Schonlein purpura nephritis (13%) and lupus nephritis (9%) were the most common secondary glomerular diseases. The proportion of minimal change disease was significant higher in boys (38%) than in girls (13%), whereas lupus nephritis was more prevalent in girls (20%) than in boys (3%). Purpura nephritis (23%) was the major pathologic pattern in younger children (0-12 years old), whereas minimal change disease (33%) was the most common glomerulopathy in adolescents (13-18 years old). The clinicopathologic correlations were slightly different between sexes and age groups. We observed increases in the proportions of minimal change disease, purpura nephritis, and membranous nephropathy over the study period that were contemporaneous with a fall in the proportion of FSGS.
CONCLUSIONS: The spectrum of glomerular diseases among children varied across sexes, age groups, and regions and changed substantially from 2004 to 2014 in China.
| Errataetall: |
CommentIn: Clin J Am Soc Nephrol. 2018 Jul 6;13(7):977-978. - PMID 29915130 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Clinical journal of the American Society of Nephrology : CJASN - 13(2018), 7 vom: 06. Juli, Seite 1047-1054 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nie, Sheng [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 18.12.2019 Date Revised 13.08.2023 published: Print-Electronic CommentIn: Clin J Am Soc Nephrol. 2018 Jul 6;13(7):977-978. - PMID 29915130 Citation Status MEDLINE |
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| doi: |
10.2215/CJN.11461017 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM285591398 |
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| 100 | 1 | |a Nie, Sheng |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The Spectrum of Biopsy-Proven Glomerular Diseases among Children in China |b A National, Cross-Sectional Survey |
| 264 | 1 | |c 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 18.12.2019 | ||
| 500 | |a Date Revised 13.08.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Clin J Am Soc Nephrol. 2018 Jul 6;13(7):977-978. - PMID 29915130 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2018 by the American Society of Nephrology. | ||
| 520 | |a BACKGROUND AND OBJECTIVES: High-quality epidemiologic data on the spectrum of biopsy-proven glomerular diseases among children are limited. This study aimed to determine the profile of and temporal change in biopsy-proven pediatric glomerular diseases in China | ||
| 520 | |a DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We previously conducted a nationwide kidney biopsy survey including 71,151 patients over an 11-year period from January 2004 to December 2014. A total of 7962 children younger than 18 years old from 115 hospitals across China with biopsy-proven glomerular diseases were included in this study. The demographic and clinical variables were extracted from referral records and pathology reports. The composition of pediatric glomerular diseases and clinicopathologic correlations in different sexes, age groups, and regions were assessed. The changing patterns of common glomerulopathies over the study period were examined | ||
| 520 | |a RESULTS: Nephrotic syndrome (50%) was the most frequent indication for kidney biopsy in children. Minimal change disease was the most common primary glomerular disease (29%) followed by IgA nephropathy (17%). Henoch-Schonlein purpura nephritis (13%) and lupus nephritis (9%) were the most common secondary glomerular diseases. The proportion of minimal change disease was significant higher in boys (38%) than in girls (13%), whereas lupus nephritis was more prevalent in girls (20%) than in boys (3%). Purpura nephritis (23%) was the major pathologic pattern in younger children (0-12 years old), whereas minimal change disease (33%) was the most common glomerulopathy in adolescents (13-18 years old). The clinicopathologic correlations were slightly different between sexes and age groups. We observed increases in the proportions of minimal change disease, purpura nephritis, and membranous nephropathy over the study period that were contemporaneous with a fall in the proportion of FSGS | ||
| 520 | |a CONCLUSIONS: The spectrum of glomerular diseases among children varied across sexes, age groups, and regions and changed substantially from 2004 to 2014 in China | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Adolescent | |
| 650 | 4 | |a Biopsy | |
| 650 | 4 | |a Child | |
| 650 | 4 | |a China | |
| 650 | 4 | |a Demography | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Glomerulonephritis, IgA | |
| 650 | 4 | |a Glomerulonephritis, Membranous | |
| 650 | 4 | |a Glomerulosclerosis, Focal Segmental | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Kidney Glomerulus | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Nephrosis, Lipoid | |
| 650 | 4 | |a Purpura, Schoenlein-Henoch | |
| 650 | 4 | |a Referral and Consultation | |
| 650 | 4 | |a Surveys and Questionnaires | |
| 650 | 4 | |a glomerular disease | |
| 650 | 4 | |a glomerulonephritis | |
| 650 | 4 | |a kidney | |
| 650 | 4 | |a kidney biopsy | |
| 650 | 4 | |a lupus nephritis | |
| 650 | 4 | |a nephrotic syndrome | |
| 650 | 4 | |a pediatrics | |
| 700 | 1 | |a He, Wenjuan |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Ting |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Diankun |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Guobao |e verfasserin |4 aut | |
| 700 | 1 | |a Geng, Jian |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Nan |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Gang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Luo, Yang |e verfasserin |4 aut | |
| 700 | 1 | |a Nie, Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Hou, Fan Fan |e verfasserin |4 aut | |
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