Risk of peripheral artery disease according to a healthy lifestyle score : The PREDIMED study
Copyright © 2018 Elsevier B.V. All rights reserved..
BACKGROUND AND AIMS: The PREDIMED (PREvención con DIeta MEDiterránea) is a multicentre trial analyzed as a prospective cohort study. A total of 7122 participants (aged 55-80 years) at high risk of cardiovascular disease in the PREDIMED trial were recruited in 11 centres in Spain. The prevalence of subjects with type 2 diabetes was 50%. Our objective was to determine the contribution of lifestyle factors to the development of peripheral artery disease (PAD).
METHODS: Incident clinical PAD in relation to a healthy lifestyle 5-point score defined as adherence to a Mediterranean diet (MedDiet), moderate alcohol intake, regular physical activity, normal weight (BMI<25) and non-smoking was measured.
RESULTS: Eighty-seven incident PAD cases were diagnosed during a median follow-up of 4.8 years. Compared with participants with 0 or 1 healthy lifestyle factor, the multivariable hazard ratio for PAD was 0.65 (95% confidence interval (CI) 0.37 to 1.14) for 2 factors, and 0.40 (0.22-0.72) for 3 or more. Moderate alcohol consumption, non-smoking, physical activity and following a MedDiet were significantly inversely associated with PAD whereas no association was found for normal weight (BMI<25 kg/m2). PAD risk monotonically decreased with an increasing number of lifestyle factors, and the greatest reduction was found for a score combining moderate alcohol consumption, MedDiet and physical activity or non-smoking. The multivariable-adjusted population attributable risk percent for the combination of these 4 factors was 80.5% (95% CI: 21.3%-95.1%).
CONCLUSIONS: Our results demonstrate that a simple healthy lifestyle score is associated with a substantially reduced risk of PAD in a high cardiovascular risk population with a high prevalence (50%) of subjects with type 2 diabetes.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:275 |
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| Enthalten in: |
Atherosclerosis - 275(2018) vom: 05. Aug., Seite 133-140 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
López-Laguna, Nieves [VerfasserIn] |
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| Links: |
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| Themen: |
Alcohol consumption |
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| Anmerkungen: |
Date Completed 22.10.2019 Date Revised 10.12.2019 published: Print-Electronic ISRCTN: SRCTN35739639 Citation Status MEDLINE |
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| doi: |
10.1016/j.atherosclerosis.2018.05.049 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM285469843 |
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| 245 | 1 | 0 | |a Risk of peripheral artery disease according to a healthy lifestyle score |b The PREDIMED study |
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| 500 | |a Date Completed 22.10.2019 | ||
| 500 | |a Date Revised 10.12.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ISRCTN: SRCTN35739639 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2018 Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND AND AIMS: The PREDIMED (PREvención con DIeta MEDiterránea) is a multicentre trial analyzed as a prospective cohort study. A total of 7122 participants (aged 55-80 years) at high risk of cardiovascular disease in the PREDIMED trial were recruited in 11 centres in Spain. The prevalence of subjects with type 2 diabetes was 50%. Our objective was to determine the contribution of lifestyle factors to the development of peripheral artery disease (PAD) | ||
| 520 | |a METHODS: Incident clinical PAD in relation to a healthy lifestyle 5-point score defined as adherence to a Mediterranean diet (MedDiet), moderate alcohol intake, regular physical activity, normal weight (BMI<25) and non-smoking was measured | ||
| 520 | |a RESULTS: Eighty-seven incident PAD cases were diagnosed during a median follow-up of 4.8 years. Compared with participants with 0 or 1 healthy lifestyle factor, the multivariable hazard ratio for PAD was 0.65 (95% confidence interval (CI) 0.37 to 1.14) for 2 factors, and 0.40 (0.22-0.72) for 3 or more. Moderate alcohol consumption, non-smoking, physical activity and following a MedDiet were significantly inversely associated with PAD whereas no association was found for normal weight (BMI<25 kg/m2). PAD risk monotonically decreased with an increasing number of lifestyle factors, and the greatest reduction was found for a score combining moderate alcohol consumption, MedDiet and physical activity or non-smoking. The multivariable-adjusted population attributable risk percent for the combination of these 4 factors was 80.5% (95% CI: 21.3%-95.1%) | ||
| 520 | |a CONCLUSIONS: Our results demonstrate that a simple healthy lifestyle score is associated with a substantially reduced risk of PAD in a high cardiovascular risk population with a high prevalence (50%) of subjects with type 2 diabetes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Alcohol consumption | |
| 650 | 4 | |a Healthy lifestyle | |
| 650 | 4 | |a Mediterranean diet | |
| 650 | 4 | |a Peripheral artery disease | |
| 650 | 4 | |a Physical activity | |
| 650 | 4 | |a Smoking | |
| 700 | 1 | |a Martínez-González, Miguel A |e verfasserin |4 aut | |
| 700 | 1 | |a Toledo, Estefania |e verfasserin |4 aut | |
| 700 | 1 | |a Babio, Nancy |e verfasserin |4 aut | |
| 700 | 1 | |a Sorlí, José V |e verfasserin |4 aut | |
| 700 | 1 | |a Ros, Emilio |e verfasserin |4 aut | |
| 700 | 1 | |a Muñoz, Miguel Ángel |e verfasserin |4 aut | |
| 700 | 1 | |a Estruch, Ramon |e verfasserin |4 aut | |
| 700 | 1 | |a Lapetra, José |e verfasserin |4 aut | |
| 700 | 1 | |a Muñoz-Bravo, Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Fiol, Miquel |e verfasserin |4 aut | |
| 700 | 1 | |a Serra-Majem, Lluís |e verfasserin |4 aut | |
| 700 | 1 | |a Pintó, Xavier |e verfasserin |4 aut | |
| 700 | 1 | |a González, José I |e verfasserin |4 aut | |
| 700 | 1 | |a Fitó, Montse |e verfasserin |4 aut | |
| 700 | 1 | |a Basora, Josep |e verfasserin |4 aut | |
| 700 | 1 | |a Arós, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Ruiz-Canela, Miguel |e verfasserin |4 aut | |
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