Right ventricular base/apex ratio in the assessment of pediatric pulmonary arterial hypertension : Results from the European Pediatric Pulmonary Vascular Disease Network
© 2018 Wiley Periodicals, Inc..
BACKGROUND: Echocardiographic determination of RV end-systolic base/apex (RVES b/a) ratio was proposed to be of clinical value for assessment of pulmonary arterial hypertension (PAH) in adults.
HYPOTHESIS: We hypothesized that the RVES b/a ratio will be affected in children with PAH and aimed to correlate RVES b/a ratio with conventionally used echocardiographic and hemodynamic variables, and with New York Heart Association (NYHA) functional class.
METHODS: First we determined normal pediatric values for RVES b/a ratio in 157 healthy children (68 males; age range, 0.5-17.7 years). We then conducted an echocardiographic study in 51 children with PAH (29 males; age range, 0.3-17.8 years).
RESULTS: RVES b/a ratio was lower compared with age- and sex-matched healthy controls (P < 0.001). In children with PAH, RVES b/a ratio decreased with worsening NYHA class. RVES b/a ratio inversely correlated with RV/LV end-systolic diameter ratio (ρ = -0.450, P = 0.001) but did not correlate with RV systolic function parameters (eg, tricuspid annular plane systolic excursion) and correlated with cardiac catheterization-determined pulmonary vascular resistance index (ρ = -0.571, P < 0.001). ROC analysis unraveled excellent performance of RVES b/a ratio to detect PAH in children (AUC: 0.95, 95% CI: 0.89-1.00, P < 0.001).
CONCLUSIONS: The RVES b/a ratio decreased in children with PAH compared with age- and sex-matched healthy subjects. The RVES b/a ratio inversely correlated with both echocardiographic and hemodynamic indicators of increased RV pressure afterload and with NYHA class, suggesting that RVES b/a ratio reflects disease severity in PAH children.
| Errataetall: |
CommentIn: Clin Cardiol. 2018 Sep;41(9):1150-1151. - PMID 30069895 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
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| Enthalten in: |
Clinical cardiology - 41(2018), 9 vom: 13. Sept., Seite 1144-1149 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Koestenberger, Martin [VerfasserIn] |
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| Links: |
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| Themen: |
Comparative Study |
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| Anmerkungen: |
Date Completed 08.11.2018 Date Revised 09.01.2021 published: Print-Electronic CommentIn: Clin Cardiol. 2018 Sep;41(9):1150-1151. - PMID 30069895 Citation Status MEDLINE |
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| doi: |
10.1002/clc.22994 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM285412582 |
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| 100 | 1 | |a Koestenberger, Martin |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Right ventricular base/apex ratio in the assessment of pediatric pulmonary arterial hypertension |b Results from the European Pediatric Pulmonary Vascular Disease Network |
| 264 | 1 | |c 2018 | |
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| 500 | |a Date Completed 08.11.2018 | ||
| 500 | |a Date Revised 09.01.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Clin Cardiol. 2018 Sep;41(9):1150-1151. - PMID 30069895 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2018 Wiley Periodicals, Inc. | ||
| 520 | |a BACKGROUND: Echocardiographic determination of RV end-systolic base/apex (RVES b/a) ratio was proposed to be of clinical value for assessment of pulmonary arterial hypertension (PAH) in adults | ||
| 520 | |a HYPOTHESIS: We hypothesized that the RVES b/a ratio will be affected in children with PAH and aimed to correlate RVES b/a ratio with conventionally used echocardiographic and hemodynamic variables, and with New York Heart Association (NYHA) functional class | ||
| 520 | |a METHODS: First we determined normal pediatric values for RVES b/a ratio in 157 healthy children (68 males; age range, 0.5-17.7 years). We then conducted an echocardiographic study in 51 children with PAH (29 males; age range, 0.3-17.8 years) | ||
| 520 | |a RESULTS: RVES b/a ratio was lower compared with age- and sex-matched healthy controls (P < 0.001). In children with PAH, RVES b/a ratio decreased with worsening NYHA class. RVES b/a ratio inversely correlated with RV/LV end-systolic diameter ratio (ρ = -0.450, P = 0.001) but did not correlate with RV systolic function parameters (eg, tricuspid annular plane systolic excursion) and correlated with cardiac catheterization-determined pulmonary vascular resistance index (ρ = -0.571, P < 0.001). ROC analysis unraveled excellent performance of RVES b/a ratio to detect PAH in children (AUC: 0.95, 95% CI: 0.89-1.00, P < 0.001) | ||
| 520 | |a CONCLUSIONS: The RVES b/a ratio decreased in children with PAH compared with age- and sex-matched healthy subjects. The RVES b/a ratio inversely correlated with both echocardiographic and hemodynamic indicators of increased RV pressure afterload and with NYHA class, suggesting that RVES b/a ratio reflects disease severity in PAH children | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Echocardiography | |
| 650 | 4 | |a End-Systolic Base/Apex Ratio | |
| 650 | 4 | |a Pediatric | |
| 650 | 4 | |a Pulmonary Arterial Hypertension | |
| 650 | 4 | |a Right Ventricle | |
| 700 | 1 | |a Avian, Alexander |e verfasserin |4 aut | |
| 700 | 1 | |a Gamillscheg, Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Sallmon, Hannes |e verfasserin |4 aut | |
| 700 | 1 | |a Grangl, Gernot |e verfasserin |4 aut | |
| 700 | 1 | |a Burmas, Ante |e verfasserin |4 aut | |
| 700 | 1 | |a Schweintzger, Sabrina |e verfasserin |4 aut | |
| 700 | 1 | |a Kurath-Koller, Stefan |e verfasserin |4 aut | |
| 700 | 1 | |a Cvirn, Gerhard |e verfasserin |4 aut | |
| 700 | 1 | |a Hansmann, Georg |e verfasserin |4 aut | |
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