Distribution of influenza virus types by age using case-based global surveillance data from twenty-nine countries, 1999-2014
BACKGROUND: Influenza disease burden varies by age and this has important public health implications. We compared the proportional distribution of different influenza virus types within age strata using surveillance data from twenty-nine countries during 1999-2014 (N=358,796 influenza cases).
METHODS: For each virus, we calculated a Relative Illness Ratio (defined as the ratio of the percentage of cases in an age group to the percentage of the country population in the same age group) for young children (0-4 years), older children (5-17 years), young adults (18-39 years), older adults (40-64 years), and the elderly (65+ years). We used random-effects meta-analysis models to obtain summary relative illness ratios (sRIRs), and conducted meta-regression and sub-group analyses to explore causes of between-estimates heterogeneity.
RESULTS: The influenza virus with highest sRIR was A(H1N1) for young children, B for older children, A(H1N1)pdm2009 for adults, and (A(H3N2) for the elderly. As expected, considering the diverse nature of the national surveillance datasets included in our analysis, between-estimates heterogeneity was high (I2>90%) for most sRIRs. The variations of countries' geographic, demographic and economic characteristics and the proportion of outpatients among reported influenza cases explained only part of the heterogeneity, suggesting that multiple factors were at play.
CONCLUSIONS: These results highlight the importance of presenting burden of disease estimates by age group and virus (sub)type.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
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| Enthalten in: |
BMC infectious diseases - 18(2018), 1 vom: 08. Juni, Seite 269 |
| Sprache: |
Englisch |
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| Links: |
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| Themen: |
Age distribution |
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| Anmerkungen: |
Date Completed 23.04.2019 Date Revised 08.04.2022 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12879-018-3181-y |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM285288024 |
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| 100 | 1 | |a Caini, Saverio |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Distribution of influenza virus types by age using case-based global surveillance data from twenty-nine countries, 1999-2014 |
| 264 | 1 | |c 2018 | |
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| 500 | |a Date Completed 23.04.2019 | ||
| 500 | |a Date Revised 08.04.2022 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Influenza disease burden varies by age and this has important public health implications. We compared the proportional distribution of different influenza virus types within age strata using surveillance data from twenty-nine countries during 1999-2014 (N=358,796 influenza cases) | ||
| 520 | |a METHODS: For each virus, we calculated a Relative Illness Ratio (defined as the ratio of the percentage of cases in an age group to the percentage of the country population in the same age group) for young children (0-4 years), older children (5-17 years), young adults (18-39 years), older adults (40-64 years), and the elderly (65+ years). We used random-effects meta-analysis models to obtain summary relative illness ratios (sRIRs), and conducted meta-regression and sub-group analyses to explore causes of between-estimates heterogeneity | ||
| 520 | |a RESULTS: The influenza virus with highest sRIR was A(H1N1) for young children, B for older children, A(H1N1)pdm2009 for adults, and (A(H3N2) for the elderly. As expected, considering the diverse nature of the national surveillance datasets included in our analysis, between-estimates heterogeneity was high (I2>90%) for most sRIRs. The variations of countries' geographic, demographic and economic characteristics and the proportion of outpatients among reported influenza cases explained only part of the heterogeneity, suggesting that multiple factors were at play | ||
| 520 | |a CONCLUSIONS: These results highlight the importance of presenting burden of disease estimates by age group and virus (sub)type | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Age distribution | |
| 650 | 4 | |a H1N1 subtype | |
| 650 | 4 | |a H3N2 subtype | |
| 650 | 4 | |a Influenza | |
| 650 | 4 | |a Influenza A virus | |
| 650 | 4 | |a Influenza B virus | |
| 650 | 4 | |a Meta-analysis | |
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| 700 | 1 | |a Kusznierz, Gabriela F |e verfasserin |4 aut | |
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