Results of the treatment in selected infertile patients with high density of endometrial NK cells CD56+ and CD16+ Second part
INTRODUCTION: This statements follows the first part of our publication entitled Screening of endometrial NK cells in selected infertile patients (First part - Methods and current results), where we dealt with methodology and endometrial findings of the natural killer cells CD16+ and CD56+. These cells are among the most important in preimplantaion, and in implantation period, in early pregnancy too, but can also negatively influence above mentioned processes.
OBJECTIVE: We focused on the immunomodulatory treatment with intramuscular immunoglobulins in 21 infertile patients with a high density of endometrial NK cells CD16+ and CD56+.
DESIGN: Original work-prospective study.
SETTING: Genetics-Pilsen.
METHODS: From the originally investigated 57 women aged 25-41 (average 34) years with their history of 3-9 abortions, we target on a high selective subgroup of 21 infertile patients with pathological density of endometrial NK cells CD56+ and CD16+.
RESULTS: Twelve patients underwent immunomodulatory treatment with intramuscular immunoglobulin in time of positive HCG and went on the therapeutic scheme, nine infertile women continued with IVF-ET but did not achieve HCG positivity despite of initial treatment with immunoglobulins. Of the 12 treated patients, seven of them gave a birth to healthy babies, as to the next five pregnancies - one was extrauterine pregnancy, one genetically defective fetus, three pregnancies go on successfully.Nine women from the IVF program did not get pregnat.
CONCLUSION: Immunomodulatory treatment with immunoglobulins also influences endometrial NK cells CD56+ and CD16+ associating with an overproduction of embryocytoxic cytokines. Treatment of our patients with the pathological endometrial density of NK cells must be solved strictly individually.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
Summer 2023 |
|---|---|
| Erschienen: |
Summer |
| Enthalten in: |
Zur Gesamtaufnahme - volume:83 |
|---|---|
| Enthalten in: |
Ceska gynekologie - 83(2023), 2 vom: 18., Seite 115-118 |
| Sprache: |
Tschechisch |
|---|
| Weiterer Titel: |
Výsledky léčby u vybraných infertilních pacientek s vysokou denzitou endometriálních NK buněk CD56+ a CD16+ Druhá část |
|---|
| Beteiligte Personen: |
Ulčová-Gallová, Z [VerfasserIn] |
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| Themen: |
CD56 Antigen |
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| Anmerkungen: |
Date Completed 07.08.2018 Date Revised 02.12.2018 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM285145029 |
|---|
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| 100 | 1 | |a Ulčová-Gallová, Z |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Results of the treatment in selected infertile patients with high density of endometrial NK cells CD56+ and CD16+ Second part |
| 246 | 3 | 3 | |a Výsledky léčby u vybraných infertilních pacientek s vysokou denzitou endometriálních NK buněk CD56+ a CD16+ Druhá část |
| 264 | 1 | |c Summer | |
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| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 07.08.2018 | ||
| 500 | |a Date Revised 02.12.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a INTRODUCTION: This statements follows the first part of our publication entitled Screening of endometrial NK cells in selected infertile patients (First part - Methods and current results), where we dealt with methodology and endometrial findings of the natural killer cells CD16+ and CD56+. These cells are among the most important in preimplantaion, and in implantation period, in early pregnancy too, but can also negatively influence above mentioned processes | ||
| 520 | |a OBJECTIVE: We focused on the immunomodulatory treatment with intramuscular immunoglobulins in 21 infertile patients with a high density of endometrial NK cells CD16+ and CD56+ | ||
| 520 | |a DESIGN: Original work-prospective study | ||
| 520 | |a SETTING: Genetics-Pilsen | ||
| 520 | |a METHODS: From the originally investigated 57 women aged 25-41 (average 34) years with their history of 3-9 abortions, we target on a high selective subgroup of 21 infertile patients with pathological density of endometrial NK cells CD56+ and CD16+ | ||
| 520 | |a RESULTS: Twelve patients underwent immunomodulatory treatment with intramuscular immunoglobulin in time of positive HCG and went on the therapeutic scheme, nine infertile women continued with IVF-ET but did not achieve HCG positivity despite of initial treatment with immunoglobulins. Of the 12 treated patients, seven of them gave a birth to healthy babies, as to the next five pregnancies - one was extrauterine pregnancy, one genetically defective fetus, three pregnancies go on successfully.Nine women from the IVF program did not get pregnat | ||
| 520 | |a CONCLUSION: Immunomodulatory treatment with immunoglobulins also influences endometrial NK cells CD56+ and CD16+ associating with an overproduction of embryocytoxic cytokines. Treatment of our patients with the pathological endometrial density of NK cells must be solved strictly individually | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a immunoglobulins | |
| 650 | 4 | |a infertility | |
| 650 | 4 | |a natural killer cells endometrium. | |
| 650 | 4 | |a treatment | |
| 650 | 7 | |a CD56 Antigen |2 NLM | |
| 650 | 7 | |a Chorionic Gonadotropin |2 NLM | |
| 650 | 7 | |a Receptors, IgG |2 NLM | |
| 700 | 1 | |a Pešek, M |e verfasserin |4 aut | |
| 700 | 1 | |a Haschová, M |e verfasserin |4 aut | |
| 700 | 1 | |a Chaloupka, P |e verfasserin |4 aut | |
| 700 | 1 | |a Mukenšnabl, P |e verfasserin |4 aut | |
| 700 | 1 | |a Cibulka, J |e verfasserin |4 aut | |
| 700 | 1 | |a Lošan, P |e verfasserin |4 aut | |
| 700 | 1 | |a Bibková, K |e verfasserin |4 aut | |
| 700 | 1 | |a Mičanová, Z |e verfasserin |4 aut | |
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