Scan-rescan reproducibility of segmental aortic wall shear stress as assessed by phase-specific segmentation with 4D flow MRI in healthy volunteers
OBJECTIVE: The aim was to investigate scan-rescan reproducibility and observer variability of segmental aortic 3D systolic wall shear stress (WSS) by phase-specific segmentation with 4D flow MRI in healthy volunteers.
MATERIALS AND METHODS: Ten healthy volunteers (age 26.5 ± 2.6 years) underwent aortic 4D flow MRI twice. Maximum 3D systolic WSS (WSSmax) and mean 3D systolic WSS (WSSmean) for five thoracic aortic segments over five systolic cardiac phases by phase-specific segmentations were calculated. Scan-rescan analysis and observer reproducibility analysis were performed.
RESULTS: Scan-rescan data showed overall good reproducibility for WSSmean (coefficient of variation, COV 10-15%) with moderate-to-strong intraclass correlation coefficient (ICC 0.63-0.89). The variability in WSSmax was high (COV 16-31%) with moderate-to-good ICC (0.55-0.79) for different aortic segments. Intra- and interobserver reproducibility was good-to-excellent for regional aortic WSSmax (ICC ≥ 0.78; COV ≤ 17%) and strong-to-excellent for WSSmean (ICC ≥ 0.86; COV ≤ 11%). In general, ascending aortic segments showed more WSSmax/WSSmean variability compared to aortic arch or descending aortic segments for scan-rescan, intraobserver and interobserver comparison.
CONCLUSIONS: Scan-rescan reproducibility was good for WSSmean and moderate for WSSmax for all thoracic aortic segments over multiple systolic phases in healthy volunteers. Intra/interobserver reproducibility for segmental WSS assessment was good-to-excellent. Variability of WSSmax is higher and should be taken into account in case of individual follow-up or in comparative rest-stress studies to avoid misinterpretation.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2018 |
|---|---|
| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
|---|---|
| Enthalten in: |
Magma (New York, N.Y.) - 31(2018), 5 vom: 26. Okt., Seite 653-663 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
van der Palen, Roel L F [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 07.01.2019 Date Revised 07.01.2019 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1007/s10334-018-0688-6 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM284497649 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM284497649 | ||
| 003 | DE-627 | ||
| 005 | 20231225043344.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10334-018-0688-6 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0948.xml |
| 035 | |a (DE-627)NLM284497649 | ||
| 035 | |a (NLM)29804208 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a van der Palen, Roel L F |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Scan-rescan reproducibility of segmental aortic wall shear stress as assessed by phase-specific segmentation with 4D flow MRI in healthy volunteers |
| 264 | 1 | |c 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 07.01.2019 | ||
| 500 | |a Date Revised 07.01.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: The aim was to investigate scan-rescan reproducibility and observer variability of segmental aortic 3D systolic wall shear stress (WSS) by phase-specific segmentation with 4D flow MRI in healthy volunteers | ||
| 520 | |a MATERIALS AND METHODS: Ten healthy volunteers (age 26.5 ± 2.6 years) underwent aortic 4D flow MRI twice. Maximum 3D systolic WSS (WSSmax) and mean 3D systolic WSS (WSSmean) for five thoracic aortic segments over five systolic cardiac phases by phase-specific segmentations were calculated. Scan-rescan analysis and observer reproducibility analysis were performed | ||
| 520 | |a RESULTS: Scan-rescan data showed overall good reproducibility for WSSmean (coefficient of variation, COV 10-15%) with moderate-to-strong intraclass correlation coefficient (ICC 0.63-0.89). The variability in WSSmax was high (COV 16-31%) with moderate-to-good ICC (0.55-0.79) for different aortic segments. Intra- and interobserver reproducibility was good-to-excellent for regional aortic WSSmax (ICC ≥ 0.78; COV ≤ 17%) and strong-to-excellent for WSSmean (ICC ≥ 0.86; COV ≤ 11%). In general, ascending aortic segments showed more WSSmax/WSSmean variability compared to aortic arch or descending aortic segments for scan-rescan, intraobserver and interobserver comparison | ||
| 520 | |a CONCLUSIONS: Scan-rescan reproducibility was good for WSSmean and moderate for WSSmax for all thoracic aortic segments over multiple systolic phases in healthy volunteers. Intra/interobserver reproducibility for segmental WSS assessment was good-to-excellent. Variability of WSSmax is higher and should be taken into account in case of individual follow-up or in comparative rest-stress studies to avoid misinterpretation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 4D flow MRI | |
| 650 | 4 | |a Aorta | |
| 650 | 4 | |a Aortopathy | |
| 650 | 4 | |a Wall shear stress | |
| 700 | 1 | |a Roest, Arno A W |e verfasserin |4 aut | |
| 700 | 1 | |a van den Boogaard, Pieter J |e verfasserin |4 aut | |
| 700 | 1 | |a de Roos, Albert |e verfasserin |4 aut | |
| 700 | 1 | |a Blom, Nico A |e verfasserin |4 aut | |
| 700 | 1 | |a Westenberg, Jos J M |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Magma (New York, N.Y.) |d 1997 |g 31(2018), 5 vom: 26. Okt., Seite 653-663 |w (DE-627)NLM074735586 |x 1352-8661 |7 nnns |
| 773 | 1 | 8 | |g volume:31 |g year:2018 |g number:5 |g day:26 |g month:10 |g pages:653-663 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s10334-018-0688-6 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 31 |j 2018 |e 5 |b 26 |c 10 |h 653-663 | ||