Age-adjusted Charlson Comorbidity Index Does Not Predict Outcomes in Patients Submitted to Noninvasive Ventilation
Copyright © 2018 SEPAR. Publicado por Elsevier España, S.L.U. All rights reserved..
INTRODUCTION: Comorbidities are thought to have prognostic impact on outcomes of patients submitted to noninvasive ventilation (NIV). Our goal was to determine if age-adjusted Charlson comorbidity index (ACCI) could predict outcomes in patients undergoing NIV due to acute respiratory failure.
METHODS: Patients in respiratory failure submitted to NIV were prospective evaluated comparing patient's characteristics and outcomes according to ACCI≤median vs. ACCI>median. Each comorbidity composing the index was tested as predictor of NIV failure and readmission/mortality risk at 30 and 90 days, using logistic regression analysis. NIV failure was defined as need for invasive mechanical ventilation and/or death.
RESULTS: 177 patients were enrolled. Median ACCI score was 5 points. Comparing patients with ACCI>5 with ACCI≤5, the former group was older but APACHE II was similar. Time to first NIV disconnection was inferior for ACCI>5 patients (OR 0.46, 95% CI 0.23-0.89, p=0.021), after gender and age adjustment. No differences were found in length of stay, time on NIV, NIV complications or failure, and 30 and 90-day hospital readmission or death, before and after adjustment. None of the single comorbidities was predictive of NIV failure and readmission risk, when adjusted to sex and age.
CONCLUSION: ACCI is not a good predictor for short and medium-term outcomes in patients submitted to NIV.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:54 |
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| Enthalten in: |
Archivos de bronconeumologia - 54(2018), 10 vom: 25. Okt., Seite 503-509 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Meireles, Mariana [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 19.09.2019 Date Revised 18.05.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.arbres.2018.03.001 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM284472433 |
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| 500 | |a Date Revised 18.05.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2018 SEPAR. Publicado por Elsevier España, S.L.U. All rights reserved. | ||
| 520 | |a INTRODUCTION: Comorbidities are thought to have prognostic impact on outcomes of patients submitted to noninvasive ventilation (NIV). Our goal was to determine if age-adjusted Charlson comorbidity index (ACCI) could predict outcomes in patients undergoing NIV due to acute respiratory failure | ||
| 520 | |a METHODS: Patients in respiratory failure submitted to NIV were prospective evaluated comparing patient's characteristics and outcomes according to ACCI≤median vs. ACCI>median. Each comorbidity composing the index was tested as predictor of NIV failure and readmission/mortality risk at 30 and 90 days, using logistic regression analysis. NIV failure was defined as need for invasive mechanical ventilation and/or death | ||
| 520 | |a RESULTS: 177 patients were enrolled. Median ACCI score was 5 points. Comparing patients with ACCI>5 with ACCI≤5, the former group was older but APACHE II was similar. Time to first NIV disconnection was inferior for ACCI>5 patients (OR 0.46, 95% CI 0.23-0.89, p=0.021), after gender and age adjustment. No differences were found in length of stay, time on NIV, NIV complications or failure, and 30 and 90-day hospital readmission or death, before and after adjustment. None of the single comorbidities was predictive of NIV failure and readmission risk, when adjusted to sex and age | ||
| 520 | |a CONCLUSION: ACCI is not a good predictor for short and medium-term outcomes in patients submitted to NIV | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Age-adjusted Charlson comorbidity index | |
| 650 | 4 | |a Ancianos | |
| 650 | 4 | |a Comorbidities | |
| 650 | 4 | |a Comorbilidades | |
| 650 | 4 | |a Elderly | |
| 650 | 4 | |a Insuficiencia respiratoria | |
| 650 | 4 | |a Noninvasive ventilation | |
| 650 | 4 | |a Outcomes | |
| 650 | 4 | |a Respiratory failure | |
| 650 | 4 | |a Resultados | |
| 650 | 4 | |a Ventilación no invasiva | |
| 650 | 4 | |a Índice de comorbilidad de Charlson ajustado por edad | |
| 700 | 1 | |a Machado, Ana |e verfasserin |4 aut | |
| 700 | 1 | |a Lopes, Juliana |e verfasserin |4 aut | |
| 700 | 1 | |a Abreu, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Furtado, Inês |e verfasserin |4 aut | |
| 700 | 1 | |a Gonçalves, João |e verfasserin |4 aut | |
| 700 | 1 | |a Costa, Ana Rita |e verfasserin |4 aut | |
| 700 | 1 | |a Mateus, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Neves, João |e verfasserin |4 aut | |
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