Resolution effects in reconstructing ancestral genomes
BACKGROUND: The reconstruction of ancestral genomes must deal with the problem of resolution, necessarily involving a trade-off between trying to identify genomic details and being overwhelmed by noise at higher resolutions.
RESULTS: We use the median reconstruction at the synteny block level, of the ancestral genome of the order Gentianales, based on coffee, Rhazya stricta and grape, to exemplify the effects of resolution (granularity) on comparative genomic analyses.
CONCLUSIONS: We show how decreased resolution blurs the differences between evolving genomes, with respect to rate, mutational process and other characteristics.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
BMC genomics - 19(2018), Suppl 2 vom: 09. Mai, Seite 100 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zheng, Chunfang [VerfasserIn] |
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| Links: |
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| Themen: |
Gene order |
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| Anmerkungen: |
Date Completed 17.12.2018 Date Revised 17.12.2018 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12864-018-4462-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM284106968 |
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| 520 | |a BACKGROUND: The reconstruction of ancestral genomes must deal with the problem of resolution, necessarily involving a trade-off between trying to identify genomic details and being overwhelmed by noise at higher resolutions | ||
| 520 | |a RESULTS: We use the median reconstruction at the synteny block level, of the ancestral genome of the order Gentianales, based on coffee, Rhazya stricta and grape, to exemplify the effects of resolution (granularity) on comparative genomic analyses | ||
| 520 | |a CONCLUSIONS: We show how decreased resolution blurs the differences between evolving genomes, with respect to rate, mutational process and other characteristics | ||
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| 700 | 1 | |a Sankoff, David |e verfasserin |4 aut | |
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