Association between comorbid cancer and outcomes among admissions for acute ischemic stroke receiving systemic thrombolysis
BACKGROUND: The impact of cancer on outcomes was not assessed in major trials of systemic thrombolysis in acute ischemic stroke.
AIMS: To evaluate the association between comorbid cancer and hospital outcomes among patients receiving systemic thrombolysis for the treatment of acute ischemic stroke.
METHODS: The 2013 and 2014 United States National Inpatient Sample was used to identify adult patients hospitalized for acute ischemic stroke who received systemic thrombolysis. Identified admissions were stratified into two cohorts based on the presence or absence of comorbid cancer. Multivariable logistic regression was performed to determine the association between comorbid cancer and the odds of in-hospital mortality and intracerebral hemorrhage after adjustment for age ≥75 years and comorbid atrial fibrillation.
RESULTS: A total of 13,993 acute ischemic stroke admissions were treated with systemic thrombolysis. Of these, 3.0% ( n = 416) had comorbid cancer. The overall incidence of in-hospital mortality was 7.0% and intracerebral hemorrhage occurred in 7.6% of patients. Upon multivariable adjustment, comorbid cancer was not associated with an increased odds of in-hospital mortality (odds ratio = 1.24; 95% confidence interval = 0.88-1.76). However, the adjusted odds of intracerebral hemorrhage were higher among those with comorbid cancer (odds ratio = 1.60; 95% confidence interval = 1.17-2.17).
CONCLUSIONS: In this retrospective study of admissions for acute ischemic stroke receiving thrombolysis, comorbid cancer was not associated with a higher odds of in-hospital mortality but was associated with an increased odds of intracerebral hemorrhage. Factors driving this observed association should be explored in data sets containing clinical variables.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2019 |
|---|---|
| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
|---|---|
| Enthalten in: |
International journal of stroke : official journal of the International Stroke Society - 14(2019), 1 vom: 15. Jan., Seite 48-52 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Weeda, Erin R [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Intracerebral hemorrhage |
|---|
| Anmerkungen: |
Date Completed 18.12.2019 Date Revised 18.12.2019 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1177/1747493018778135 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM284086789 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM284086789 | ||
| 003 | DE-627 | ||
| 005 | 20231225042408.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1177/1747493018778135 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0946.xml |
| 035 | |a (DE-627)NLM284086789 | ||
| 035 | |a (NLM)29762085 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Weeda, Erin R |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Association between comorbid cancer and outcomes among admissions for acute ischemic stroke receiving systemic thrombolysis |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 18.12.2019 | ||
| 500 | |a Date Revised 18.12.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: The impact of cancer on outcomes was not assessed in major trials of systemic thrombolysis in acute ischemic stroke | ||
| 520 | |a AIMS: To evaluate the association between comorbid cancer and hospital outcomes among patients receiving systemic thrombolysis for the treatment of acute ischemic stroke | ||
| 520 | |a METHODS: The 2013 and 2014 United States National Inpatient Sample was used to identify adult patients hospitalized for acute ischemic stroke who received systemic thrombolysis. Identified admissions were stratified into two cohorts based on the presence or absence of comorbid cancer. Multivariable logistic regression was performed to determine the association between comorbid cancer and the odds of in-hospital mortality and intracerebral hemorrhage after adjustment for age ≥75 years and comorbid atrial fibrillation | ||
| 520 | |a RESULTS: A total of 13,993 acute ischemic stroke admissions were treated with systemic thrombolysis. Of these, 3.0% ( n = 416) had comorbid cancer. The overall incidence of in-hospital mortality was 7.0% and intracerebral hemorrhage occurred in 7.6% of patients. Upon multivariable adjustment, comorbid cancer was not associated with an increased odds of in-hospital mortality (odds ratio = 1.24; 95% confidence interval = 0.88-1.76). However, the adjusted odds of intracerebral hemorrhage were higher among those with comorbid cancer (odds ratio = 1.60; 95% confidence interval = 1.17-2.17) | ||
| 520 | |a CONCLUSIONS: In this retrospective study of admissions for acute ischemic stroke receiving thrombolysis, comorbid cancer was not associated with a higher odds of in-hospital mortality but was associated with an increased odds of intracerebral hemorrhage. Factors driving this observed association should be explored in data sets containing clinical variables | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Stroke | |
| 650 | 4 | |a intracerebral hemorrhage | |
| 650 | 4 | |a mortality | |
| 650 | 4 | |a neoplasms | |
| 650 | 4 | |a thrombolysis | |
| 650 | 4 | |a thrombolytic therapy | |
| 650 | 4 | |a tissue plasminogen activator | |
| 700 | 1 | |a Bohm, Nicole |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of stroke : official journal of the International Stroke Society |d 2006 |g 14(2019), 1 vom: 15. Jan., Seite 48-52 |w (DE-627)NLM181612585 |x 1747-4949 |7 nnns |
| 773 | 1 | 8 | |g volume:14 |g year:2019 |g number:1 |g day:15 |g month:01 |g pages:48-52 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1177/1747493018778135 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 14 |j 2019 |e 1 |b 15 |c 01 |h 48-52 | ||