Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging
Copyright © 2018 Elsevier Inc. All rights reserved..
Diet has a profound effect on tissue regeneration in diverse organisms, and low caloric states such as intermittent fasting have beneficial effects on organismal health and age-associated loss of tissue function. The role of adult stem and progenitor cells in responding to short-term fasting and whether such responses improve regeneration are not well studied. Here we show that a 24 hr fast augments intestinal stem cell (ISC) function in young and aged mice by inducing a fatty acid oxidation (FAO) program and that pharmacological activation of this program mimics many effects of fasting. Acute genetic disruption of Cpt1a, the rate-limiting enzyme in FAO, abrogates ISC-enhancing effects of fasting, but long-term Cpt1a deletion decreases ISC numbers and function, implicating a role for FAO in ISC maintenance. These findings highlight a role for FAO in mediating pro-regenerative effects of fasting in intestinal biology, and they may represent a viable strategy for enhancing intestinal regeneration.
Errataetall: |
CommentIn: Cell Stem Cell. 2018 May 3;22(5):611-612. - PMID 29727673 |
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Medienart: |
E-Artikel |
Erscheinungsjahr: |
2018 |
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Erschienen: |
2018 |
Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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Enthalten in: |
Cell stem cell - 22(2018), 5 vom: 03. Mai, Seite 769-778.e4 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Mihaylova, Maria M [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Completed 05.09.2019 Date Revised 06.09.2019 published: Print CommentIn: Cell Stem Cell. 2018 May 3;22(5):611-612. - PMID 29727673 Citation Status MEDLINE |
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doi: |
10.1016/j.stem.2018.04.001 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM283748036 |
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520 | |a Copyright © 2018 Elsevier Inc. All rights reserved. | ||
520 | |a Diet has a profound effect on tissue regeneration in diverse organisms, and low caloric states such as intermittent fasting have beneficial effects on organismal health and age-associated loss of tissue function. The role of adult stem and progenitor cells in responding to short-term fasting and whether such responses improve regeneration are not well studied. Here we show that a 24 hr fast augments intestinal stem cell (ISC) function in young and aged mice by inducing a fatty acid oxidation (FAO) program and that pharmacological activation of this program mimics many effects of fasting. Acute genetic disruption of Cpt1a, the rate-limiting enzyme in FAO, abrogates ISC-enhancing effects of fasting, but long-term Cpt1a deletion decreases ISC numbers and function, implicating a role for FAO in ISC maintenance. These findings highlight a role for FAO in mediating pro-regenerative effects of fasting in intestinal biology, and they may represent a viable strategy for enhancing intestinal regeneration | ||
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