Environmental Panels as a Proxy for Nursing Facility Patients With Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus Colonization
Background: Most nursing facilities (NFs) lack methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) surveillance programs due to limited resources and high costs. We investigated the utility of environmental screening of high-touch surfaces in patient rooms as a way to circumvent these challenges.
Methods: We compared MRSA and VRE culture data from high-touch surfaces in patients' rooms (14450 samples from 6 NFs) and ranked each site's performance in predicting patient colonization (7413 samples). The best-performing sites were included in a MRSA- and a VRE-specific panel that functioned as a proxy for patient colonization. Molecular typing was performed to confirm available concordant patient-environment pairs.
Results: We identified and validated a MRSA panel that consisted of the bed controls, nurse call button, bed rail, and TV remote control. The VRE panel included the toilet seat, bed controls, bed rail, TV remote control, and top of the side table. Panel colonization data tracked patient colonization. Negative predictive values were 89%-92% for MRSA and 82%-84% for VRE. Molecular typing confirmed a strong clonal type relationship in available concordant patient-environment pairs (98% for MRSA, 91% for VRE), pointing to common epidemiological patterns for environmental and patient isolates.
Conclusions: Environmental panels used as a proxy for patient colonization and incorporated into facility surveillance protocols can guide decolonization strategies, improve awareness of MRSA and VRE burden, and inform efforts to reduce transmission. Targeted environmental screening may be a viable surveillance strategy for MRSA and VRE detection in NFs.
| Errataetall: |
ErratumIn: Clin Infect Dis. 2018 Aug 31;67(6):987. - PMID 29767692 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:67 |
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| Enthalten in: |
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 67(2018), 6 vom: 31. Aug., Seite 861-868 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cassone, Marco [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 04.11.2019 Date Revised 26.11.2019 published: Print ErratumIn: Clin Infect Dis. 2018 Aug 31;67(6):987. - PMID 29767692 Citation Status MEDLINE |
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| doi: |
10.1093/cid/ciy115 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM28374023X |
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| 100 | 1 | |a Cassone, Marco |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Environmental Panels as a Proxy for Nursing Facility Patients With Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus Colonization |
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| 500 | |a Date Revised 26.11.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a ErratumIn: Clin Infect Dis. 2018 Aug 31;67(6):987. - PMID 29767692 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Background: Most nursing facilities (NFs) lack methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) surveillance programs due to limited resources and high costs. We investigated the utility of environmental screening of high-touch surfaces in patient rooms as a way to circumvent these challenges | ||
| 520 | |a Methods: We compared MRSA and VRE culture data from high-touch surfaces in patients' rooms (14450 samples from 6 NFs) and ranked each site's performance in predicting patient colonization (7413 samples). The best-performing sites were included in a MRSA- and a VRE-specific panel that functioned as a proxy for patient colonization. Molecular typing was performed to confirm available concordant patient-environment pairs | ||
| 520 | |a Results: We identified and validated a MRSA panel that consisted of the bed controls, nurse call button, bed rail, and TV remote control. The VRE panel included the toilet seat, bed controls, bed rail, TV remote control, and top of the side table. Panel colonization data tracked patient colonization. Negative predictive values were 89%-92% for MRSA and 82%-84% for VRE. Molecular typing confirmed a strong clonal type relationship in available concordant patient-environment pairs (98% for MRSA, 91% for VRE), pointing to common epidemiological patterns for environmental and patient isolates | ||
| 520 | |a Conclusions: Environmental panels used as a proxy for patient colonization and incorporated into facility surveillance protocols can guide decolonization strategies, improve awareness of MRSA and VRE burden, and inform efforts to reduce transmission. Targeted environmental screening may be a viable surveillance strategy for MRSA and VRE detection in NFs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
| 700 | 1 | |a Mantey, Julia |e verfasserin |4 aut | |
| 700 | 1 | |a Perri, Mary Beth |e verfasserin |4 aut | |
| 700 | 1 | |a Gibson, Kristen |e verfasserin |4 aut | |
| 700 | 1 | |a Lansing, Bonnie |e verfasserin |4 aut | |
| 700 | 1 | |a McNamara, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Patel, Payal K |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Vincent C C |e verfasserin |4 aut | |
| 700 | 1 | |a Walters, Maroya S |e verfasserin |4 aut | |
| 700 | 1 | |a Stone, Nimalie D |e verfasserin |4 aut | |
| 700 | 1 | |a Zervos, Marcus J |e verfasserin |4 aut | |
| 700 | 1 | |a Mody, Lona |e verfasserin |4 aut | |
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