Low fertility in vivo resulting from female factors causes small litter size in 129 inbred mice
PURPOSE: 129 inbred mice show poor reproductive ability, as evidenced by small litters; however, the exact cause of this is unknown. In the present in vivo study we examined fertility and subsequent post-implantation development in an attempt to clarify the cause of small litter size in 129 mice.
METHODS: 129 or C57BL/6J females that displayed vaginal plugs 1 day after mating with males of the same strain were examined for the presence of fertilized eggs. Reciprocal matings were also performed between 129 and C57BL/6J mice. Subsequent post-implantation development of fertilized eggs was examined by dissecting females 18-19 days after the vaginal plugs were found.
RESULTS: Mean numbers of recovered eggs were 7.9 and 8.0 in 129 and C57BL/6J mice, respectively. Half of the recovered eggs were unfertilized in 129 mice, whereas all were fertilized in C57BL/6J mice. Mean numbers of live fetuses 18-19 days after mating were significantly lower in 129 mice (4.7) than in C57BL/6J mice (7.3). In different types of pairings using both strains of mice, the fertility was significantly lower whenever 129 females were used.
CONCLUSIONS: The small litter size in 129 mice is caused by low fertility resulting from female factors.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2009 |
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Erschienen: |
2009 |
Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
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Enthalten in: |
Reproductive medicine and biology - 8(2009), 4 vom: 27. Dez., Seite 157-161 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Hino, Toshiaki [VerfasserIn] |
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Links: |
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Themen: |
129 mice |
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Anmerkungen: |
Date Revised 17.03.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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doi: |
10.1007/s12522-009-0024-y |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM283469307 |
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245 | 1 | 0 | |a Low fertility in vivo resulting from female factors causes small litter size in 129 inbred mice |
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520 | |a PURPOSE: 129 inbred mice show poor reproductive ability, as evidenced by small litters; however, the exact cause of this is unknown. In the present in vivo study we examined fertility and subsequent post-implantation development in an attempt to clarify the cause of small litter size in 129 mice | ||
520 | |a METHODS: 129 or C57BL/6J females that displayed vaginal plugs 1 day after mating with males of the same strain were examined for the presence of fertilized eggs. Reciprocal matings were also performed between 129 and C57BL/6J mice. Subsequent post-implantation development of fertilized eggs was examined by dissecting females 18-19 days after the vaginal plugs were found | ||
520 | |a RESULTS: Mean numbers of recovered eggs were 7.9 and 8.0 in 129 and C57BL/6J mice, respectively. Half of the recovered eggs were unfertilized in 129 mice, whereas all were fertilized in C57BL/6J mice. Mean numbers of live fetuses 18-19 days after mating were significantly lower in 129 mice (4.7) than in C57BL/6J mice (7.3). In different types of pairings using both strains of mice, the fertility was significantly lower whenever 129 females were used | ||
520 | |a CONCLUSIONS: The small litter size in 129 mice is caused by low fertility resulting from female factors | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a 129 mice | |
650 | 4 | |a Female factors | |
650 | 4 | |a Fertility in vivo | |
650 | 4 | |a Poor reproduction | |
650 | 4 | |a Small litter size | |
700 | 1 | |a Oda, Kanako |e verfasserin |4 aut | |
700 | 1 | |a Nakamura, Kenji |e verfasserin |4 aut | |
700 | 1 | |a Toyoda, Yutaka |e verfasserin |4 aut | |
700 | 1 | |a Yokoyama, Minesuke |e verfasserin |4 aut | |
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