THE COLLABORATIVE OCULAR TUBERCULOSIS STUDY (COTS)-1 : A Multinational Review of 251 Patients With Tubercular Retinal Vasculitis
PURPOSE: Tubercular retinal vasculitis (TRV) is a heterogeneous disease that can be difficult to manage because of nonspecific presentation and limitations of confirmatory tests for tuberculosis. This is a big data analysis on phenotypes and treatment outcomes for TRV.
METHODS: Multicentre retrospective study of patients with TRV between January 2004 and December 2014 and a minimum follow-up of 1 year.
RESULTS: Two hundred and fifty-one patients with TRV with a mean age of 38.9 ± 14.4 years (range, 9-86 years) were included. The patients were predominantly males (n = 167/251; 66.5%) of Asian ethnicity (n = 174/246; 70.7%), and geographical origin (n = 137/251; 54.6%). Most patients had features of occlusive type of RV (n = 113/185; 61.1%) except Caucasians (n = 11; 28.2%). There was no significant difference in treatment failure whether patients received antitubercular therapy (ATT) (P = 0.29), although treatment failure was less frequent in patients who received ATT (13.6%; n = 31/228) compared with those who did not (21.7%, n = 5/23). Less treatment failures were observed in patients with occlusive type RV who received ATT; however, this was not significant on survival analysis (P = 0.09). Treatment with ATT was associated with higher failure rates in patients of Hispanic and African American race and those with TRV associated with panuveitis (compared with posterior uveitis).
CONCLUSION: In this multinational study of TRV, there was no significant therapeutic effect of ATT. However, a definitive conclusion about the role of ATT could not be made because of a few patients who did not receive ATT. Because this is a retrospective study with a limited 1-year follow-up, the effect of ATT may have been overestimated (or underestimated) in the duration of follow-up.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2019 |
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Erschienen: |
2019 |
Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
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Enthalten in: |
Retina (Philadelphia, Pa.) - 39(2019), 8 vom: 01. Aug., Seite 1623-1630 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Gunasekeran, Dinesh V [VerfasserIn] |
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Links: |
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Themen: |
Antitubercular Agents |
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Anmerkungen: |
Date Completed 09.10.2020 Date Revised 09.10.2020 published: Print Citation Status MEDLINE |
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doi: |
10.1097/IAE.0000000000002194 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM283452501 |
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520 | |a PURPOSE: Tubercular retinal vasculitis (TRV) is a heterogeneous disease that can be difficult to manage because of nonspecific presentation and limitations of confirmatory tests for tuberculosis. This is a big data analysis on phenotypes and treatment outcomes for TRV | ||
520 | |a METHODS: Multicentre retrospective study of patients with TRV between January 2004 and December 2014 and a minimum follow-up of 1 year | ||
520 | |a RESULTS: Two hundred and fifty-one patients with TRV with a mean age of 38.9 ± 14.4 years (range, 9-86 years) were included. The patients were predominantly males (n = 167/251; 66.5%) of Asian ethnicity (n = 174/246; 70.7%), and geographical origin (n = 137/251; 54.6%). Most patients had features of occlusive type of RV (n = 113/185; 61.1%) except Caucasians (n = 11; 28.2%). There was no significant difference in treatment failure whether patients received antitubercular therapy (ATT) (P = 0.29), although treatment failure was less frequent in patients who received ATT (13.6%; n = 31/228) compared with those who did not (21.7%, n = 5/23). Less treatment failures were observed in patients with occlusive type RV who received ATT; however, this was not significant on survival analysis (P = 0.09). Treatment with ATT was associated with higher failure rates in patients of Hispanic and African American race and those with TRV associated with panuveitis (compared with posterior uveitis) | ||
520 | |a CONCLUSION: In this multinational study of TRV, there was no significant therapeutic effect of ATT. However, a definitive conclusion about the role of ATT could not be made because of a few patients who did not receive ATT. Because this is a retrospective study with a limited 1-year follow-up, the effect of ATT may have been overestimated (or underestimated) in the duration of follow-up | ||
650 | 4 | |a Journal Article | |
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650 | 7 | |a Immunosuppressive Agents |2 NLM | |
700 | 1 | |a Agrawal, Rupesh |e verfasserin |4 aut | |
700 | 1 | |a Agarwal, Aniruddha |e verfasserin |4 aut | |
700 | 1 | |a Carreño, Ester |e verfasserin |4 aut | |
700 | 1 | |a Raje, Dhananjay |e verfasserin |4 aut | |
700 | 1 | |a Aggarwal, Kanika |e verfasserin |4 aut | |
700 | 1 | |a Kon, Onn M |e verfasserin |4 aut | |
700 | 1 | |a Nguyen, Quan Dong |e verfasserin |4 aut | |
700 | 1 | |a Pavesio, Carlos |e verfasserin |4 aut | |
700 | 1 | |a Gupta, Vishali |e verfasserin |4 aut | |
700 | 0 | |a COTS-1 Study Group |e verfasserin |4 aut | |
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