The role of biochemical markers with special regard to troponin, CK-MB, NT-proBNP as early biomarkers of cardiotoxicity among women after chemotherapy due to breast cancer
Introduction: Cardiotoxicity ofdrugs in oncology is a growing problemwhich cardiologists and oncologistshave to struggle with. So far,researchers have been looking forbiochemical markers which couldhelp to extract a group more proneto developing complications afterchemotherapy. Authors’ reports areinconsistent in this topic.
Aim: This study assesses the roleof troponin I, CK-MB and NT-proBNP asearly predictive markers for later cardiotoxicityamong patients with breastcancer treated with chemotherapy.
Methods: One hundred five patientswith breast cancer, without either heartfailure or more than moderate severityof valvular heart diseases were qualifiedto the study.
Results: NT-proBNP concentrationsignificantly increased just after thefirst cycle of chemotherapy, either in asubgroup which developed cardiotoxicityor without this end point (p<0.001,p=0.004). CK-MB did not change significantlyduring observation. TroponinI did not change in any of the patients.During observation HDL-cholesterolconcentration significantly decreased.A transient increase of the concentrationof LDL-cholesterol had beennoted, but later it decreased belowbaseline level.
Conclusion: Troponin I has too lowsensitivity to be used as a prognosticmarker for further cardiotoxicity afterchemotherapy. No prognostic valueshave been noted of NT-proBNP andCK-MB due to the lack of differencesin both a subgroup with and withoutcardiotoxicity.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:73 |
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| Enthalten in: |
Przeglad lekarski - 73(2016), 6 vom: 01., Seite 359-63 |
| Sprache: |
Polnisch |
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| Beteiligte Personen: |
Stachowiak, Paweł [VerfasserIn] |
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| Themen: |
114471-18-0 |
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| Anmerkungen: |
Date Completed 16.05.2018 Date Revised 16.05.2018 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM283163992 |
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| 100 | 1 | |a Stachowiak, Paweł |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The role of biochemical markers with special regard to troponin, CK-MB, NT-proBNP as early biomarkers of cardiotoxicity among women after chemotherapy due to breast cancer |
| 264 | 1 | |c 2016 | |
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| 500 | |a Date Completed 16.05.2018 | ||
| 500 | |a Date Revised 16.05.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Introduction: Cardiotoxicity ofdrugs in oncology is a growing problemwhich cardiologists and oncologistshave to struggle with. So far,researchers have been looking forbiochemical markers which couldhelp to extract a group more proneto developing complications afterchemotherapy. Authors’ reports areinconsistent in this topic | ||
| 520 | |a Aim: This study assesses the roleof troponin I, CK-MB and NT-proBNP asearly predictive markers for later cardiotoxicityamong patients with breastcancer treated with chemotherapy | ||
| 520 | |a Methods: One hundred five patientswith breast cancer, without either heartfailure or more than moderate severityof valvular heart diseases were qualifiedto the study | ||
| 520 | |a Results: NT-proBNP concentrationsignificantly increased just after thefirst cycle of chemotherapy, either in asubgroup which developed cardiotoxicityor without this end point (p<0.001,p=0.004). CK-MB did not change significantlyduring observation. TroponinI did not change in any of the patients.During observation HDL-cholesterolconcentration significantly decreased.A transient increase of the concentrationof LDL-cholesterol had beennoted, but later it decreased belowbaseline level | ||
| 520 | |a Conclusion: Troponin I has too lowsensitivity to be used as a prognosticmarker for further cardiotoxicity afterchemotherapy. No prognostic valueshave been noted of NT-proBNP andCK-MB due to the lack of differencesin both a subgroup with and withoutcardiotoxicity | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Antineoplastic Agents |2 NLM | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a Peptide Fragments |2 NLM | |
| 650 | 7 | |a Troponin |2 NLM | |
| 650 | 7 | |a pro-brain natriuretic peptide (1-76) |2 NLM | |
| 650 | 7 | |a Natriuretic Peptide, Brain |2 NLM | |
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| 650 | 7 | |a Creatine Kinase, MB Form |2 NLM | |
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| 700 | 1 | |a Milchert-Leszczyńska, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Falco, Michał |e verfasserin |4 aut | |
| 700 | 1 | |a Polakowska, Małgorzata |e verfasserin |4 aut | |
| 700 | 1 | |a Wojtarowicz, Andrzej |e verfasserin |4 aut | |
| 700 | 1 | |a Kaliszczak, Robert |e verfasserin |4 aut | |
| 700 | 1 | |a Safranow, Krzysztof |e verfasserin |4 aut | |
| 700 | 1 | |a Kornacewicz-Jach, Zdzisława |e verfasserin |4 aut | |
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