Evaluation of inflammatory cells (tumor infiltrating lymphocytes - TIL) in malignant melanoma
The evaluation of inflammatory infiltrate (tumor infiltrating lymphocytes - TIL) should be a standard part of biopsy examination for malignant melanoma. Currently, the most commonly used assessment method according to Clark is not optimal and there have been attempts to find an alternative system. Here we present an overview of possible approaches involving five different evaluation methods based on hematoxylin-eosin staining, including the recent suggestion of unified TIL evaluation method for all solid tumors. The issue of methodology, prognostic and predictive significance of TIL determination as well as the importance of immunohistochemical subtyping of inflammatory infiltrate is discussed.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
Spring 2023 |
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| Erschienen: |
Spring |
| Enthalten in: |
Zur Gesamtaufnahme - volume:54 |
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| Enthalten in: |
Ceskoslovenska patologie - 54(2023), 1 vom: 10., Seite 27-31 |
| Sprache: |
Tschechisch |
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| Weiterer Titel: |
Hodnocení zánětlivé infiltrace (tumor infiltrujících lymfocytů - TIL) u maligního melanomu |
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| Beteiligte Personen: |
Dundr, Pavel [VerfasserIn] |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 24.04.2019 Date Revised 24.04.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM282803157 |
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| 245 | 1 | 0 | |a Evaluation of inflammatory cells (tumor infiltrating lymphocytes - TIL) in malignant melanoma |
| 246 | 3 | 3 | |a Hodnocení zánětlivé infiltrace (tumor infiltrujících lymfocytů - TIL) u maligního melanomu |
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| 500 | |a Date Completed 24.04.2019 | ||
| 500 | |a Date Revised 24.04.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The evaluation of inflammatory infiltrate (tumor infiltrating lymphocytes - TIL) should be a standard part of biopsy examination for malignant melanoma. Currently, the most commonly used assessment method according to Clark is not optimal and there have been attempts to find an alternative system. Here we present an overview of possible approaches involving five different evaluation methods based on hematoxylin-eosin staining, including the recent suggestion of unified TIL evaluation method for all solid tumors. The issue of methodology, prognostic and predictive significance of TIL determination as well as the importance of immunohistochemical subtyping of inflammatory infiltrate is discussed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a malignant melanoma - tumor infiltrating lymphocytes - prediction - prognosis. | |
| 700 | 1 | |a Němejcová, Kristýna |e verfasserin |4 aut | |
| 700 | 1 | |a Bártů, Michaela |e verfasserin |4 aut | |
| 700 | 1 | |a Tichá, Ivana |e verfasserin |4 aut | |
| 700 | 1 | |a Jakša, Radek |e verfasserin |4 aut | |
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