Evaluation of the neuroprotective and antidiabetic potential of phenol-rich extracts from virgin olive oils by in vitro assays
Copyright © 2018 Elsevier Ltd. All rights reserved..
In this work, phenol-rich extracts from 'Cornicabra' and 'Picual' virgin-olive oils (EVOOs) were examined, for the first time, to establish their capacity to inhibit key enzymes involved in Alzheimer's disease (AD) (acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and 5-lipoxygenase (LOX)), major depressive disorder (MDD) and Parkinson's disease (PD) (monoamine oxidases: hMAO-A and hMAO-B respectively), and diabetes mellitus (DM) (α-glucosidase and α-amylase). 'Cornicabra' displayed the best inhibitory activity against all enzymes, when compared to 'Picual': BuChE (IC50 = 156 ± 4 and 308 ± 33 mg mL-1), LOX (IC50 = 26 ± 0.5 and 37 ± 3 mg mL-1), hMAO-A (IC50 = 20 ± 2 and 37 ± 0.2 mg mL-1), hMAO-B (IC50 = 131 ± 7 and 215 ± 13 mg mL-1) and α-glucosidase (IC50 = 154 ± 17 and 251 ± 31 mg mL-1), respectively. The behaviour observed can be associated with the higher content of secoiridoids, lignans and phenolic acids in 'Cornicabra' EVOO.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:106 |
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| Enthalten in: |
Food research international (Ottawa, Ont.) - 106(2018) vom: 27. Apr., Seite 558-567 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Figueiredo-González, M [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 30.09.2019 Date Revised 30.09.2019 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.foodres.2018.01.026 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM282352511 |
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| 245 | 1 | 0 | |a Evaluation of the neuroprotective and antidiabetic potential of phenol-rich extracts from virgin olive oils by in vitro assays |
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| 500 | |a Date Revised 30.09.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2018 Elsevier Ltd. All rights reserved. | ||
| 520 | |a In this work, phenol-rich extracts from 'Cornicabra' and 'Picual' virgin-olive oils (EVOOs) were examined, for the first time, to establish their capacity to inhibit key enzymes involved in Alzheimer's disease (AD) (acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and 5-lipoxygenase (LOX)), major depressive disorder (MDD) and Parkinson's disease (PD) (monoamine oxidases: hMAO-A and hMAO-B respectively), and diabetes mellitus (DM) (α-glucosidase and α-amylase). 'Cornicabra' displayed the best inhibitory activity against all enzymes, when compared to 'Picual': BuChE (IC50 = 156 ± 4 and 308 ± 33 mg mL-1), LOX (IC50 = 26 ± 0.5 and 37 ± 3 mg mL-1), hMAO-A (IC50 = 20 ± 2 and 37 ± 0.2 mg mL-1), hMAO-B (IC50 = 131 ± 7 and 215 ± 13 mg mL-1) and α-glucosidase (IC50 = 154 ± 17 and 251 ± 31 mg mL-1), respectively. The behaviour observed can be associated with the higher content of secoiridoids, lignans and phenolic acids in 'Cornicabra' EVOO | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Cornicabra cv. | |
| 650 | 4 | |a Diabetes mellitus | |
| 650 | 4 | |a Extra-virgin olive oil | |
| 650 | 4 | |a Neuroprotection | |
| 650 | 4 | |a Phenols | |
| 650 | 4 | |a Picual cv. | |
| 650 | 7 | |a Antidepressive Agents |2 NLM | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a Antiparkinson Agents |2 NLM | |
| 650 | 7 | |a Cholinesterase Inhibitors |2 NLM | |
| 650 | 7 | |a Glycoside Hydrolase Inhibitors |2 NLM | |
| 650 | 7 | |a Lipoxygenase Inhibitors |2 NLM | |
| 650 | 7 | |a Monoamine Oxidase Inhibitors |2 NLM | |
| 650 | 7 | |a Neuroprotective Agents |2 NLM | |
| 650 | 7 | |a Olive Oil |2 NLM | |
| 650 | 7 | |a Phenols |2 NLM | |
| 650 | 7 | |a Arachidonate 5-Lipoxygenase |2 NLM | |
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| 650 | 7 | |a monoamine oxidase A, human |2 NLM | |
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| 650 | 7 | |a Acetylcholinesterase |2 NLM | |
| 650 | 7 | |a EC 3.1.1.7 |2 NLM | |
| 650 | 7 | |a Butyrylcholinesterase |2 NLM | |
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| 650 | 7 | |a EC 3.2.1.20 |2 NLM | |
| 700 | 1 | |a Reboredo-Rodríguez, P |e verfasserin |4 aut | |
| 700 | 1 | |a González-Barreiro, C |e verfasserin |4 aut | |
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