Oxidative stress-mediated influence of plasma DPP4 activity to BDNF ratio on mild cognitive impairment in elderly type 2 diabetic patients : results from the GDMD study in China
Copyright © 2018. Published by Elsevier Inc..
OBJECTIVE: Increased dipeptidyl peptidase-4 (DPP4) activity and reduced brain-derived neurotrophic factor (BDNF) in peripheral circulation are both associated with a high risk of mild cognitive impairment (MCI) in the elderly. Hence, we aimed to investigate the association between plasma DPP4 activity to BDNF ratio (DBR) and MCI in elderly patients with type 2 diabetes.
DESIGN AND METHODS: We measured plasma DPP4 activity, BDNF levels, oxidative stress parameters, inflammatory markers and calculated DBR in 1833 elderly type 2 diabetic patients aged 60 years or older. MCI was diagnosed according to the National Institute on Aging-Alzheimer's Association workgroups criteria. Further, mediation analysis was performed to estimate the mediator role of oxidative stress on the relationship between DPP4 activity and BDNF.
RESULTS: DPP4 activity was negatively associated with BDNF (r = -0.408, P < 0.001). Oxidative stress, particularly in male participants, acted as a partial mediator in the relationship between DPP4 activity and BDNF. Participants in the highest quartile of DBR had higher nitrotyrosine, 8-isoPGF2a, interleukin-6, C-reactive protein and lower Montreal Cognitive Assessment score compared with those in the lowest quartile. The odds ratio (5.15, 95% CI 3.64-7.30) for MCI in the highest DBR quartile was significantly higher than in the lowest quartile. The risk for MCI increased with higher levels of DPP4 activity and lower levels of BDNF.
CONCLUSIONS: Oxidative stress partially mediates the inverse relationship between DPP4 and BDNF. Our data provide evidence for a strong link between DBR and MCI, suggesting DBR to be a new biomarker for MCI in type 2 diabetic patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:87 |
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| Enthalten in: |
Metabolism: clinical and experimental - 87(2018) vom: 15. Okt., Seite 105-112 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zheng, Tianpeng [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 25.03.2019 Date Revised 25.03.2019 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.metabol.2018.03.014 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM282275320 |
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| 041 | |a eng | ||
| 100 | 1 | |a Zheng, Tianpeng |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Oxidative stress-mediated influence of plasma DPP4 activity to BDNF ratio on mild cognitive impairment in elderly type 2 diabetic patients |b results from the GDMD study in China |
| 264 | 1 | |c 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 25.03.2019 | ||
| 500 | |a Date Revised 25.03.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2018. Published by Elsevier Inc. | ||
| 520 | |a OBJECTIVE: Increased dipeptidyl peptidase-4 (DPP4) activity and reduced brain-derived neurotrophic factor (BDNF) in peripheral circulation are both associated with a high risk of mild cognitive impairment (MCI) in the elderly. Hence, we aimed to investigate the association between plasma DPP4 activity to BDNF ratio (DBR) and MCI in elderly patients with type 2 diabetes | ||
| 520 | |a DESIGN AND METHODS: We measured plasma DPP4 activity, BDNF levels, oxidative stress parameters, inflammatory markers and calculated DBR in 1833 elderly type 2 diabetic patients aged 60 years or older. MCI was diagnosed according to the National Institute on Aging-Alzheimer's Association workgroups criteria. Further, mediation analysis was performed to estimate the mediator role of oxidative stress on the relationship between DPP4 activity and BDNF | ||
| 520 | |a RESULTS: DPP4 activity was negatively associated with BDNF (r = -0.408, P < 0.001). Oxidative stress, particularly in male participants, acted as a partial mediator in the relationship between DPP4 activity and BDNF. Participants in the highest quartile of DBR had higher nitrotyrosine, 8-isoPGF2a, interleukin-6, C-reactive protein and lower Montreal Cognitive Assessment score compared with those in the lowest quartile. The odds ratio (5.15, 95% CI 3.64-7.30) for MCI in the highest DBR quartile was significantly higher than in the lowest quartile. The risk for MCI increased with higher levels of DPP4 activity and lower levels of BDNF | ||
| 520 | |a CONCLUSIONS: Oxidative stress partially mediates the inverse relationship between DPP4 and BDNF. Our data provide evidence for a strong link between DBR and MCI, suggesting DBR to be a new biomarker for MCI in type 2 diabetic patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Brain-derived neurotrophic factor | |
| 650 | 4 | |a DPP4 activity to BDNF ratio | |
| 650 | 4 | |a Dipeptidyl peptidase-4 | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Mild cognitive impairment | |
| 650 | 4 | |a Oxidative stress | |
| 650 | 4 | |a Type 2 diabetes | |
| 650 | 7 | |a Brain-Derived Neurotrophic Factor |2 NLM | |
| 650 | 7 | |a BDNF protein, human |2 NLM | |
| 650 | 7 | |a 7171WSG8A2 |2 NLM | |
| 650 | 7 | |a DPP4 protein, human |2 NLM | |
| 650 | 7 | |a EC 3.4.14.5 |2 NLM | |
| 650 | 7 | |a Dipeptidyl Peptidase 4 |2 NLM | |
| 650 | 7 | |a EC 3.4.14.5 |2 NLM | |
| 700 | 1 | |a Liu, Hongbo |e verfasserin |4 aut | |
| 700 | 1 | |a Qin, Linyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xiaoxi |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Xueping |e verfasserin |4 aut | |
| 700 | 1 | |a Xiao, Liuping |e verfasserin |4 aut | |
| 700 | 1 | |a Qin, Shenghua |e verfasserin |4 aut | |
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