Non-invasive Intracranial Pressure Assessment in Brain Injured Patients Using Ultrasound-Based Methods
BACKGROUND: Non-invasive measurement of intracranial pressure (ICP) can be invaluable in the management of critically ill patients. Invasive measurement of ICP remains the "gold standard" and should be performed when clinical indications are met, but it is invasive and brings some risks. In this project, we aim to validate the non-invasive ICP (nICP) assessment models based on arterious and venous transcranial Doppler ultrasonography (TCD) and optic nerve sheath diameter (ONSD).
METHODS: We included brain injured patients requiring invasive ICP monitoring (intraparenchymal or intraventricular). We assessed the concordance between ICP measured non-invasively with arterious [flow velocity diastolic formula (ICPFVd) and pulsatility index (PI)], venous TCD (vPI) and ICP derived from ONSD (nICPONSD) compared to invasive ICP measurement.
RESULTS: Linear regression showed a positive relationship between nICP and ICP for all the methods, except PIv. ICPONSD showed the strongest correlation with invasive ICP (r = 0.61) compared to the other methods (ICPFVd, r = 0.26, p value = 0.0015; PI, r = 0.19, p value = 0.02, vPI, r = 0.056, p value = 0.510). The ability to predict intracranial hypertension was highest for ICPONSD (AUC = 0.91; 95% CI, 0.85-0.97 at ICP > 20 mmHg), with a sensitivity and specificity of 85%, followed by ICPFVd (AUC = 0.67; 95% CI, 0.54-0.79).
CONCLUSIONS: Our results demonstrate that among the non-invasive methods studied, ONSD showed the best accuracy in the detection of ICP.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:126 |
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| Enthalten in: |
Acta neurochirurgica. Supplement - 126(2018) vom: 25., Seite 69-73 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Robba, Chiara [VerfasserIn] |
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| Links: |
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| Themen: |
Brain ultrasound |
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| Anmerkungen: |
Date Completed 12.07.2018 Date Revised 29.01.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1007/978-3-319-65798-1_15 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM281500940 |
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| 100 | 1 | |a Robba, Chiara |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Non-invasive Intracranial Pressure Assessment in Brain Injured Patients Using Ultrasound-Based Methods |
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| 500 | |a Date Revised 29.01.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Non-invasive measurement of intracranial pressure (ICP) can be invaluable in the management of critically ill patients. Invasive measurement of ICP remains the "gold standard" and should be performed when clinical indications are met, but it is invasive and brings some risks. In this project, we aim to validate the non-invasive ICP (nICP) assessment models based on arterious and venous transcranial Doppler ultrasonography (TCD) and optic nerve sheath diameter (ONSD) | ||
| 520 | |a METHODS: We included brain injured patients requiring invasive ICP monitoring (intraparenchymal or intraventricular). We assessed the concordance between ICP measured non-invasively with arterious [flow velocity diastolic formula (ICPFVd) and pulsatility index (PI)], venous TCD (vPI) and ICP derived from ONSD (nICPONSD) compared to invasive ICP measurement | ||
| 520 | |a RESULTS: Linear regression showed a positive relationship between nICP and ICP for all the methods, except PIv. ICPONSD showed the strongest correlation with invasive ICP (r = 0.61) compared to the other methods (ICPFVd, r = 0.26, p value = 0.0015; PI, r = 0.19, p value = 0.02, vPI, r = 0.056, p value = 0.510). The ability to predict intracranial hypertension was highest for ICPONSD (AUC = 0.91; 95% CI, 0.85-0.97 at ICP > 20 mmHg), with a sensitivity and specificity of 85%, followed by ICPFVd (AUC = 0.67; 95% CI, 0.54-0.79) | ||
| 520 | |a CONCLUSIONS: Our results demonstrate that among the non-invasive methods studied, ONSD showed the best accuracy in the detection of ICP | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Brain ultrasound | |
| 650 | 4 | |a Intracranial pressure | |
| 650 | 4 | |a Optic nerve sheath diameter | |
| 650 | 4 | |a Transcranial doppler | |
| 700 | 1 | |a Cardim, Danilo |e verfasserin |4 aut | |
| 700 | 1 | |a Tajsic, Tamara |e verfasserin |4 aut | |
| 700 | 1 | |a Pietersen, Justine |e verfasserin |4 aut | |
| 700 | 1 | |a Bulman, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Rasulo, Frank |e verfasserin |4 aut | |
| 700 | 1 | |a Bertuetti, Rita |e verfasserin |4 aut | |
| 700 | 1 | |a Donnelly, Joseph |e verfasserin |4 aut | |
| 700 | 1 | |a Xiuyun, Liu |e verfasserin |4 aut | |
| 700 | 1 | |a Czosnyka, Zofia |e verfasserin |4 aut | |
| 700 | 1 | |a Cabeleira, Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Smielewski, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Matta, Basil |e verfasserin |4 aut | |
| 700 | 1 | |a Bertuccio, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Czosnyka, Marek |e verfasserin |4 aut | |
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