Association between PIK3CA alteration and prognosis of gastric cancer patients : a meta-analysis
BACKGROUND: Increasing evidence suggests that dysregulation of phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) plays an important role in carcinogenesis. However, the relationship between PIK3CA expression and gastric cancer (GC) prognosis remains controversial.
METHODS: We searchedPubMed, Embase, Web of Science, and the Cochrane Library databases for relevant studies up to June 30, 2017. Primary outcomes were hazard ratio (HR), odds ratio (OR), and 95% confidence intervals (CI) for association with overall survival and clinicopathological features.
RESULTS: Eleven studies comprising 2481 GC patients were analyzed. Pooled analysis showed that PIK3CA upregulation was significantly associated with worse overall survival (HR = 1.79, 95% CI 1.42-2.27, p< 0.001) at the protein (HR = 1.94, 95% CI 1.52-2.47, p< 0.001) but not the gene (HR = 1.57, 95% CI 0.92-2.69, p= 0.097) level. PIK3CA gene mutation did not correlate with overall survival (HR = 1.05, 95% CI 0.83-1.34, p= 0.666) but was significantly associated with poor tumor differentiation (OR = 0.37, 95% CI 0.17-0.76, p= 0.011).
CONCLUSION: High PIK3CA protein expression predicted poor prognosis in GC, whereas PIK3CA gene amplification or mutation did not. Moreover, PIK3CA mutation was an indicator of poorly differentiated tumors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Oncotarget - 9(2018), 7 vom: 26. Jan., Seite 7651-7659 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Hua [VerfasserIn] |
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| Links: |
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| Themen: |
Alteration |
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| Anmerkungen: |
Date Revised 13.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.18632/oncotarget.23871 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a BACKGROUND: Increasing evidence suggests that dysregulation of phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) plays an important role in carcinogenesis. However, the relationship between PIK3CA expression and gastric cancer (GC) prognosis remains controversial | ||
| 520 | |a METHODS: We searchedPubMed, Embase, Web of Science, and the Cochrane Library databases for relevant studies up to June 30, 2017. Primary outcomes were hazard ratio (HR), odds ratio (OR), and 95% confidence intervals (CI) for association with overall survival and clinicopathological features | ||
| 520 | |a RESULTS: Eleven studies comprising 2481 GC patients were analyzed. Pooled analysis showed that PIK3CA upregulation was significantly associated with worse overall survival (HR = 1.79, 95% CI 1.42-2.27, p< 0.001) at the protein (HR = 1.94, 95% CI 1.52-2.47, p< 0.001) but not the gene (HR = 1.57, 95% CI 0.92-2.69, p= 0.097) level. PIK3CA gene mutation did not correlate with overall survival (HR = 1.05, 95% CI 0.83-1.34, p= 0.666) but was significantly associated with poor tumor differentiation (OR = 0.37, 95% CI 0.17-0.76, p= 0.011) | ||
| 520 | |a CONCLUSION: High PIK3CA protein expression predicted poor prognosis in GC, whereas PIK3CA gene amplification or mutation did not. Moreover, PIK3CA mutation was an indicator of poorly differentiated tumors | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a PIK3CA | |
| 650 | 4 | |a alteration | |
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| 650 | 4 | |a meta-analysis | |
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| 700 | 1 | |a Li, Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Cui, Jianxin |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Yunhe |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Dianchao |e verfasserin |4 aut | |
| 700 | 1 | |a Luan, Shangfeng |e verfasserin |4 aut | |
| 700 | 1 | |a Qin, Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhai, Tongshan |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Dengxiang |e verfasserin |4 aut | |
| 700 | 1 | |a Huo, Zhibin |e verfasserin |4 aut | |
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