Clinical Significance of Gli-1 And Caveolin-1 Expression in theHuman Small Cell Lung Cancer
Creative Commons Attribution License.
Background: Lung cancer is the leading causes of cancer-related deaths around the world. Abnormal activation of thehedgehog (Hh) signaling pathway has been found to be involved in the occurrence, invasion, and metastasis of cancers.Autophagy also plays a significant role in the growth and metastasis of cancers. However, the correlation between theHh signaling pathway and autophagy in small cell lung cancer (SCLC) is still poorly understood. This study aimed toinvestigate the significance of Hh signaling pathway and autophagy in SCLC. Materials and Methods: The expressionof the Hh-induced transcriptional factor, glioma associated oncogene-1 (Gli-1) and the autophagy-related moleculecaveolin-1 (Cav-1) and their clinical significance was performed to detect and assay by immunohistochemistry in tissuemicroarray including 70 patients with SCLC. Results: In our study, 47 (67.1%) patients had positive Gli-1 expression,49 (70.0%) patients had positive Cav-1 expression, and 44 (62.9%) patients had negative fibroblastic Cav-1 expression.In SCLC, Gli-1 expression increased markedly, and was closely associated with decreased fibroblastic Cav-1 expression.Furthermore, we also found that Gli-1 expression was closely associated with increased Cav-1 expression. Conclusions:Our findings suggested that abnormal activation of the Hh signaling pathway is closely related to autophagy in SCLC.We envision that novel targets may come with the further investigation of Gli-1 and Cav-1 in carcinogenesis of SCLC.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
|---|---|
| Enthalten in: |
Asian Pacific journal of cancer prevention : APJCP - 19(2018), 2 vom: 26. Feb., Seite 401-406 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wu, Jie [VerfasserIn] |
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| Themen: |
Autophagy |
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| Anmerkungen: |
Date Completed 30.08.2018 Date Revised 13.11.2018 published: Electronic Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM281380570 |
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| 245 | 1 | 0 | |a Clinical Significance of Gli-1 And Caveolin-1 Expression in theHuman Small Cell Lung Cancer |
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| 500 | |a Date Revised 13.11.2018 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Creative Commons Attribution License | ||
| 520 | |a Background: Lung cancer is the leading causes of cancer-related deaths around the world. Abnormal activation of thehedgehog (Hh) signaling pathway has been found to be involved in the occurrence, invasion, and metastasis of cancers.Autophagy also plays a significant role in the growth and metastasis of cancers. However, the correlation between theHh signaling pathway and autophagy in small cell lung cancer (SCLC) is still poorly understood. This study aimed toinvestigate the significance of Hh signaling pathway and autophagy in SCLC. Materials and Methods: The expressionof the Hh-induced transcriptional factor, glioma associated oncogene-1 (Gli-1) and the autophagy-related moleculecaveolin-1 (Cav-1) and their clinical significance was performed to detect and assay by immunohistochemistry in tissuemicroarray including 70 patients with SCLC. Results: In our study, 47 (67.1%) patients had positive Gli-1 expression,49 (70.0%) patients had positive Cav-1 expression, and 44 (62.9%) patients had negative fibroblastic Cav-1 expression.In SCLC, Gli-1 expression increased markedly, and was closely associated with decreased fibroblastic Cav-1 expression.Furthermore, we also found that Gli-1 expression was closely associated with increased Cav-1 expression. Conclusions:Our findings suggested that abnormal activation of the Hh signaling pathway is closely related to autophagy in SCLC.We envision that novel targets may come with the further investigation of Gli-1 and Cav-1 in carcinogenesis of SCLC | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Small cell lung cancer | |
| 650 | 4 | |a Gli−1 | |
| 650 | 4 | |a caveolin−1 | |
| 650 | 4 | |a hedgehog pathway | |
| 650 | 4 | |a autophagy | |
| 650 | 7 | |a Biomarkers, Tumor |2 NLM | |
| 650 | 7 | |a CAV1 protein, human |2 NLM | |
| 650 | 7 | |a Caveolin 1 |2 NLM | |
| 650 | 7 | |a GLI1 protein, human |2 NLM | |
| 650 | 7 | |a Zinc Finger Protein GLI1 |2 NLM | |
| 700 | 1 | |a Di, Dingxin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Chen |e verfasserin |4 aut | |
| 700 | 1 | |a Pan, Qi |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yingyi |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xue |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Xianda |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Honglei |e verfasserin |4 aut | |
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