Central Blood Pressure and Cardiovascular Outcomes in Chronic Kidney Disease
Copyright © 2018 by the American Society of Nephrology..
BACKGROUND AND OBJECTIVES: Central BP measurements provide noninvasive measurement of aortic BP; our objectives were to examine the association of central and brachial BP measurements with risk of cardiovascular outcomes and mortality in patients with CKD and to determine the role of central BP measurement in conjunction with brachial BP in estimating cardiovascular risk.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In a prospective, longitudinal study (the Chronic Renal Insufficiency Cohort), central BP was measured in participants with CKD using the SphygmoCorPVx System. Cox proportional hazards models were used for analyses.
RESULTS: Mean age of the participants (n=2875) was 60 years old. After a median follow-up of 5.5 years, participants in the highest quartile of brachial systolic BP (≥138 mm Hg) were at higher risk for the composite cardiovascular outcome (hazard ratio, 1.59; 95% confidence interval, 1.17 to 2.17; c statistic, 0.76) but not all-cause mortality (hazard ratio, 1.28; 95% confidence interval, 0.90 to 1.80) compared with those in the lowest quartile. Participants in the highest quartile of central systolic BP were also at higher risk for the composite cardiovascular outcome (hazard ratio, 1.69; 95% confidence interval, 1.24 to 2.31; c statistic, 0.76) compared with participants in the lowest quartile.
CONCLUSIONS: We show that elevated brachial and central BP measurements are both associated with higher risk of cardiovascular disease outcomes in patients with CKD. Measurement of central BP does not improve the ability to predict cardiovascular disease outcomes or mortality in patients with CKD compared with brachial BP measurement.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Clinical journal of the American Society of Nephrology : CJASN - 13(2018), 4 vom: 06. Apr., Seite 585-595 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rahman, Mahboob [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 11.10.2019 Date Revised 26.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.2215/CJN.08620817 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM281340862 |
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| 041 | |a eng | ||
| 100 | 1 | |a Rahman, Mahboob |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Central Blood Pressure and Cardiovascular Outcomes in Chronic Kidney Disease |
| 264 | 1 | |c 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 11.10.2019 | ||
| 500 | |a Date Revised 26.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2018 by the American Society of Nephrology. | ||
| 520 | |a BACKGROUND AND OBJECTIVES: Central BP measurements provide noninvasive measurement of aortic BP; our objectives were to examine the association of central and brachial BP measurements with risk of cardiovascular outcomes and mortality in patients with CKD and to determine the role of central BP measurement in conjunction with brachial BP in estimating cardiovascular risk | ||
| 520 | |a DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In a prospective, longitudinal study (the Chronic Renal Insufficiency Cohort), central BP was measured in participants with CKD using the SphygmoCorPVx System. Cox proportional hazards models were used for analyses | ||
| 520 | |a RESULTS: Mean age of the participants (n=2875) was 60 years old. After a median follow-up of 5.5 years, participants in the highest quartile of brachial systolic BP (≥138 mm Hg) were at higher risk for the composite cardiovascular outcome (hazard ratio, 1.59; 95% confidence interval, 1.17 to 2.17; c statistic, 0.76) but not all-cause mortality (hazard ratio, 1.28; 95% confidence interval, 0.90 to 1.80) compared with those in the lowest quartile. Participants in the highest quartile of central systolic BP were also at higher risk for the composite cardiovascular outcome (hazard ratio, 1.69; 95% confidence interval, 1.24 to 2.31; c statistic, 0.76) compared with participants in the lowest quartile | ||
| 520 | |a CONCLUSIONS: We show that elevated brachial and central BP measurements are both associated with higher risk of cardiovascular disease outcomes in patients with CKD. Measurement of central BP does not improve the ability to predict cardiovascular disease outcomes or mortality in patients with CKD compared with brachial BP measurement | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Aorta | |
| 650 | 4 | |a Arterial Pressure | |
| 650 | 4 | |a Cardiovascular Diseases | |
| 650 | 4 | |a Confidence Intervals | |
| 650 | 4 | |a Follow-Up Studies | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Longitudinal Studies | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Proportional Hazards Models | |
| 650 | 4 | |a Prospective Studies | |
| 650 | 4 | |a Renal Insufficiency, Chronic | |
| 650 | 4 | |a blood pressure | |
| 650 | 4 | |a risk factors | |
| 700 | 1 | |a Hsu, Jesse Yenchih |e verfasserin |4 aut | |
| 700 | 1 | |a Desai, Niraj |e verfasserin |4 aut | |
| 700 | 1 | |a Hsu, Chi-Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Anderson, Amanda H |e verfasserin |4 aut | |
| 700 | 1 | |a Appel, Lawrence J |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Cohen, Debbie L |e verfasserin |4 aut | |
| 700 | 1 | |a Drawz, Paul E |e verfasserin |4 aut | |
| 700 | 1 | |a He, Jiang |e verfasserin |4 aut | |
| 700 | 1 | |a Qiang, Pan |e verfasserin |4 aut | |
| 700 | 1 | |a Ricardo, Ana C |e verfasserin |4 aut | |
| 700 | 1 | |a Steigerwalt, Susan |e verfasserin |4 aut | |
| 700 | 1 | |a Weir, Matthew R |e verfasserin |4 aut | |
| 700 | 1 | |a Wright, Jackson T |c Jr |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xiaoming |e verfasserin |4 aut | |
| 700 | 1 | |a Townsend, Raymond R |e verfasserin |4 aut | |
| 700 | 0 | |a CRIC Study Investigators |e verfasserin |4 aut | |
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