Pharmacokinetics, Short-term Safety and Efficacy of the Approved Once-daily Darunavir/Ritonavir Dosing Regimen in HIV-infected Children
In this multicenter pharmacokinetic study in HIV-infected children (6-12 years of age), we validated the approved once-daily darunavir/ritonavir dosing recommendations. The geometric mean darunavir area under the plasma concentration-time curve was 63.1 h·mg/L, substantially lower than the mean value observed in adults. However, all trough levels were adequate, and short-term virologic outcome was good. These data support the use of the darunavir/ritonavir once-daily dosing recommendations.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
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| Enthalten in: |
The Pediatric infectious disease journal - 37(2018), 10 vom: 01. Okt., Seite 1008-1010 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bastiaans, Diane E T [VerfasserIn] |
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| Links: |
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| Themen: |
Darunavir |
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| Anmerkungen: |
Date Completed 12.06.2019 Date Revised 10.12.2019 published: Print Citation Status MEDLINE |
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| doi: |
10.1097/INF.0000000000001964 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM281323631 |
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| 100 | 1 | |a Bastiaans, Diane E T |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Pharmacokinetics, Short-term Safety and Efficacy of the Approved Once-daily Darunavir/Ritonavir Dosing Regimen in HIV-infected Children |
| 264 | 1 | |c 2018 | |
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| 500 | |a Date Completed 12.06.2019 | ||
| 500 | |a Date Revised 10.12.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a In this multicenter pharmacokinetic study in HIV-infected children (6-12 years of age), we validated the approved once-daily darunavir/ritonavir dosing recommendations. The geometric mean darunavir area under the plasma concentration-time curve was 63.1 h·mg/L, substantially lower than the mean value observed in adults. However, all trough levels were adequate, and short-term virologic outcome was good. These data support the use of the darunavir/ritonavir once-daily dosing recommendations | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Validation Study | |
| 650 | 7 | |a HIV Protease Inhibitors |2 NLM | |
| 650 | 7 | |a Ritonavir |2 NLM | |
| 650 | 7 | |a O3J8G9O825 |2 NLM | |
| 650 | 7 | |a Darunavir |2 NLM | |
| 650 | 7 | |a YO603Y8113 |2 NLM | |
| 700 | 1 | |a Geelen, Sibyl P M |e verfasserin |4 aut | |
| 700 | 1 | |a Visser, Eline G |e verfasserin |4 aut | |
| 700 | 1 | |a van der Flier, Michiel |e verfasserin |4 aut | |
| 700 | 1 | |a Vermont, Clementien L |e verfasserin |4 aut | |
| 700 | 1 | |a Colbers, Angela P H |e verfasserin |4 aut | |
| 700 | 1 | |a Roukens, Monique |e verfasserin |4 aut | |
| 700 | 1 | |a Burger, David M |e verfasserin |4 aut | |
| 700 | 1 | |a van Rossum, Annemarie M C |e verfasserin |4 aut | |
| 700 | 0 | |a Dutch Paediatric HIV Study Group |e verfasserin |4 aut | |
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