Long non-coding RNA n326322 promotes the proliferation and invasion in nasopharyngeal carcinoma
Long non-coding RNAs (lncRNAs) have been reported to perform significant roles in cancer development and progression. Our research has found that a novel lncRNA n326322 was higher in nasopharyngeal carcinoma (NPC) cells. Moreover, the gain and loss of functional approaches revealed that the overexpression of lncRNA-n326322 promoted NPC cell proliferation and invasion, whereas the downregulation of lncRNA-n326322 suppressed cell proliferation and invasion. Further experiments demonstrated that potential mechanism may be associated with the activation of PI3K/AKT and ERK/MAPK pathways. Taken together, these results indicate that lncRNA-n326322 is associated with tumorigenesis of NPC.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Oncotarget - 9(2018), 2 vom: 05. Jan., Seite 1843-1851 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Du, Mingyu [VerfasserIn] |
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| Links: |
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| Themen: |
Invasion |
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| Anmerkungen: |
Date Revised 20.11.2019 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.18632/oncotarget.22828 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM280760914 |
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| 520 | |a Long non-coding RNAs (lncRNAs) have been reported to perform significant roles in cancer development and progression. Our research has found that a novel lncRNA n326322 was higher in nasopharyngeal carcinoma (NPC) cells. Moreover, the gain and loss of functional approaches revealed that the overexpression of lncRNA-n326322 promoted NPC cell proliferation and invasion, whereas the downregulation of lncRNA-n326322 suppressed cell proliferation and invasion. Further experiments demonstrated that potential mechanism may be associated with the activation of PI3K/AKT and ERK/MAPK pathways. Taken together, these results indicate that lncRNA-n326322 is associated with tumorigenesis of NPC | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Wu, Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Gu, Jia-Jia |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Nan |e verfasserin |4 aut | |
| 700 | 1 | |a Ding, Kai |e verfasserin |4 aut | |
| 700 | 1 | |a Qian, Lu-Xi |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Zhi-Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Wen-Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Tian, Xiao-Kang |e verfasserin |4 aut | |
| 700 | 1 | |a He, Xia |e verfasserin |4 aut | |
| 700 | 1 | |a Yin, Li |e verfasserin |4 aut | |
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